Dynamics of Proteins and Nucleic Acids

Erscheinungsjahr 2004
ISBN: 978-0-521-35652-7
Verlag: Cambridge University Press

Buch, Englisch, 246 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 408 g

This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.

Autoren/Hrsg.

McCammon, J. Andrew

Harvey, Stephen C.

Fachgebiete

• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Chemie Physikalische Chemie Quantenchemie, Theoretische Chemie
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Biowissenschaften Enzymologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Physik Angewandte Physik Biophysik

Inhaltsverzeichnis

Preface; 1. Introduction; 2. Structure of proteins, nucleic acids, and their solvent surroundings; 3. Dynamics of proteins, nucleic acids, and their solvent surroundings; 4. Theoretical methods; 5. Short time dynamics; 6. Local structural transitions; 7. Global structural changes; 8. Dynamics of molecular associations; 9. Recent developments and future directions; Appendices; References; Index.