Mitochondria and Neurotoxicity

Erscheinungsjahr 2025
ISBN: 978-0-443-24056-0
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 450 g

Mitochondria and Neurotoxicity, Volume Thirteen in the Advances in Neurotoxicology series, presents interesting chapters written by an international board of authors. Chapters in this new release include Introduction to mitochondrial toxicity: form, function, and signaling, Respirometry parameters as indicators of neurotoxicity, Pesticide exposure and hippocampal neurogenesis: Role of ER stress and mitochondria, Gene Therapy Approaches to Abrogate Pathogenic Mechanisms in Parkinson’s disease, Mitochondrial dysfunction induced by trichloroethylene in Parkinson’s disease, and Gut-brain axis inflammation induced by mitochondrial toxicants.

Autoren/Hrsg.

Weitere Mitwirkende

Costa, Lucio G.

Aschner, Michael

Tieu, Kim

Fachgebiete

• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Sozialwissenschaften Psychologie Allgemeine Psychologie Biologische Psychologie, Neuropsychologie

Inhaltsverzeichnis

1. Introduction to mitochondrial toxicity: form, function, and signaling.
Jeremy W. Chambers and Monica Moncada Restrepo
2. Respirometry parameters as indicators of neurotoxicity.
Jeremy W. Chambers and Monica Moncada Restrepo
3. Pesticide exposure and hippocampal neurogenesis: Role of ER stress and mitochondria.
Muhammad M. Hossain
4. Gene Therapy Approaches to Abrogate Pathogenic Mechanisms in Parkinson’s disease
Victor Tapias Molina
5. Mitochondrial dysfunction induced by trichloroethylene in Parkinson’s disease
Neda Ilieva, Ashley Adamson, Mohammed Ghalib, Teel Walters and Briana R. De Miranda
6. Gut-brain axis inflammation induced by mitochondrial toxicants.
Souvarish Sarkar, Abdulla Abu Salah, Aiesha Anchan and Pablo Reina-Gonzalez
7. TBD
Jason R. Cannon

Über Autor(innen)

Aschner, Michael
Dr. Aschner serves as the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine. He served on numerous toxicology panels (Institute of Medicine, US Environmental Protection Agency, Center for Disease Control), and is a member of the Neurotoxicology and Alcohol study section (NIH). Research in our lab focuses on the following topics: (1) Modulation of C. elegans genes (aat, skn-1, daf-16) that are homologous to mammalian regulators of MeHg uptake and cellular resistance will modify dopaminergic neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation of cytoprotective genes that combat MeHg-induced oxidative injury, and that genetic and biochemical changes that negatively impact upon Nrf2 function increase MeHg's neurotoxicity. (3) PARK2, a strong PD genetic risk factor, alters neuronal vulnerability to modifiers of cellular Mn status, particularly at the level of mitochondrial dysfunction and oxidative stress. Our studies are designed to (1) shed novel mechanistic insight into metal-induced neurodegeneration; (2) identify targets for genetic or pharmacologic modulation of neurodegenerative disorders; (3) increase knowledge of the pathway involved in oxidative stress; (4) develop improved research models for human disease using knowledge of environmental sciences.

Costa, Lucio G.
Dr. Lucio G. Costa is Professor of Toxicology at the University of Washington in Seattle, and of Pharmacology/Toxicology at the University of Parma Medical School. He received a doctorate in Pharmacology from the University of Milano in 1977, and was a postdoctoral fellow at the University of Texas at Houston. He is a member of several national and international professional organizations, a Fellow of the Academy of Toxicological Sciences, and a European Certified Toxicologist. He received various award for his scientific accomplishments, including the Achievement Award from the Society of Toxicology. He serves in various editorial capacities for several toxicology journals, and is an active manuscript and grant reviewer. Dr. Costa has been the member of dozens of panels and committees at the national and international level dealing with toxicology and risk assessment issues. He has chaired and/or organized symposia at scientific meetings in the United States and internationally. He has been teaching classes in the area of toxicology, neurotoxicology and pharmacology to graduate and medical students for 30 years. He keeps an active research program in the area of neurotoxicology.