Cytoskeletal Mechanics

Models and Measurements in Cell Mechanics
Erscheinungsjahr 2014
ISBN: 978-0-521-84637-0
Verlag: Cambridge University Press

Buch, Englisch, 252 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 683 g

Reihe: Cambridge Texts in Biomedical Engineering

The purpose of this book is to present a full spectrum of views on current approaches to modeling cell mechanics. In part, this diversity of opinions stems from the different backgrounds of those who have contributed to the field. The authors of this book come from the biophysics, bioengineering, and physical chemistry communities, and each joins the discussion with their own unique perspective on biological systems. Consequently, the approaches range from finite element methods as commonly used in continuum mechanics, to models of the cytoskeleton as a cross-linked polymer network, to models of glassy materials and gels. Studies reflect both the static, instantaneous nature of the structure as well as its dynamic nature due to polymerization and the full array of biological processes. It is unlikely that a single, unifying approach will evolve from this diversity, in part because of the complexity of the phenomena underlying the mechanical properties of the cell. It is our hope, however, that a better appreciation of the various perspectives will lead to a more highly coordinated approach to these essential problems, and might facilitate discussions among those with differing views.

Autoren/Hrsg.

Mofrad, Mohammad R. K.

Kamm, Roger D.

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Chemie Physikalische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik

Inhaltsverzeichnis

1. Introduction and the biological basis for cell mechanics Mohammad R. K. Mofrad and Roger Kamm
2. Experimental measurements of intracellular mechanics Paul Janmey and Christoph Schmidt
3. The cytoskeleton as a soft glassy material Jeffrey Fredberg and Ben Fabry
4. Continuum elastic or viscoelastic models for the cell Mohammad R. K. Mofrad, Helene Karcher and Roger Kamm
5. Multiphasic models of cell mechanics Farshid Guuilak, Mansoor A. Haider, Lori A. Setton, Tod A. Laursen and Frank P. T. Baaijens
6. Models of cytoskeletal mechanics based on tensegrity Dimitrije Stamenovic
7. Cells, gels and mechanics Gerald H. Pollack
8. Polymer-based models of cytoskeletal networks F. C. MacKintosh
9. Cell dynamics and the actin cytoskeleton James L. McGrath and C. Forbes Dewey, Jr
10. Active cellular motion: continuum theories and models Marc Herant and Micah Dembo
11. Summary Mohammad R. K. Mofrad and Roger Kamm.

Über Autor(innen)

Mofrad, Mohammad R. K.
Dr. Mohammad Reza Kaazempur Mofrad is an Assistant Professor at the University of California, Berkley's Department of Bioengineering. His research at the Mofrad Lab is focused around understanding the principles underlying cellular mechanics, rheology, and mechanotransduction, as well as the multiscale biomechanical processes underlying cardiovascular tissue mechanotransduction involved in diseases like aortic valve calcification and arterial atherosclerosis. Before joining the faculty at Berkeley, Dr. Mofrad was a Principal Research Scientist at MIT for nearly two years.He is the recipient of the Partner in Excellence Award from Partners HealthCare System, Massachusetts General Hospital. He is also the co-editor of Cellular Mechanotransduction.

Kamm, Roger D.
Roger D. Kamm has been on the faculty at MIT since receiving his Ph.D. in 1977 and now holds a joint appointment in the Biological Engineering and Mechanical Engineering Departments. Current research activities in the Kamm Laboratory at MIT include tissue engineering and microfluidics, cellular rheology and molecular mechanics. He is currently the Chair of the U.S. National Committee on Biomechanics and the World Council on Biomechanics, and he is Director of the Global Enterprise for MicroMechanics and Molecular Medicine. Kamm has a long-standing interest in bioengineering education, directs a NIH-funded biomechanics training program, co-chaired the committee to form MIT's new undergraduate major in biological engineering, and helped to develop MIT's course on molecular, cellular, and tissue biomechanics.