Molecular Targets and Therapeutic Design

Erscheinungsjahr 2026
ISBN: 978-0-443-34523-4
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 450 g

Molecular Targets and Therapeutic Design provides a comprehensive overview of the current landscape and future directions in the identification and exploitation of molecular targets for the development of new therapeutics. This volume brings together leading experts to discuss the fundamental principles of target discovery, validation, and the strategies used to design molecules that modulate biological pathways in disease.

Topics covered include the structural and functional characterization of targets, the use of computational and high-throughput screening methods, advances in drug design and development, and emerging technologies such as gene editing and biologics. The book also explores challenges and opportunities in translating basic research findings into clinical applications, with case studies highlighting successful examples from oncology, infectious diseases, neurological disorders, and more.

Autoren/Hrsg.

Weitere Mitwirkende

Donev, Rossen

Fachgebiete

• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

1. Recent Strategies and Approaches for the Development of Molecularly Targeted Nanomedicine
Balak Das Kurmi, Preeti Patel and Aman Kumar
2. Transcriptomic Profiling for Therapeutic Target Discovery in Neuropsychiatric Conditions
Karthick Vasudevan
3. Transcriptomic Insights into Hormone-Driven Malignancies: Toward Targeted Therapeutic Strategies
Karthick Vasudevan
4. Targeting Kinases in Neurodegenerative Diseases and Cancer: Structural Insights and Therapeutic Strategies
Anas Shamsi
5. Small molecular therapeutic targets for neurodegenerative diseases
Subashchandrabose Chinnathambi, Nagaraj Rangappa, Riddhi Bharatkumar Upadhyay, Sivasamy Ramasamy, Murugan Sevanan and Nathish Lakshman
6. Signaling cascades of Tau protein
Subashchandrabose Chinnathambi
7. Understanding molecular role of lipids for Alzheimer's disease
Subashchandrabose Chinnathambi
8. Neuroinflammation- molecular target based therapeutic approach
Deepraj Paul
9. Clinical Challenges and Therapeutic Strategies in Chordoma
Margot Martinez-Moreno and Beatrice Campilan
10. Molecular Characterization and Experimental Models of Chordoma
Margot Martinez-Moreno and Beatrice Campilan
11. Disordered Proteins as Fuzzy Viral Drug Targets
Selvaraj Chandrabose Sr.
12. Marine-Derived Bioactives as Precision Modulators of Molecular Targets: Emerging Paradigms in Therapeutic Design
Selvaraj Chandrabose Sr.
13. Precision Therapeutics for Wound Healing: Molecular Targets, Signaling Networks, and Advanced Drug Design Strategies
Ashokkumar Sibiya
14. Exploring the efficacy of ?-lactam and ?-lactamase inhibitors/?-lactam enhancer against carbapenem-resistant Acinetobacter baumannii: An in vitro and in silico analysis
George Priya Doss C
15. Screening of prospective biofilm-inhibitory drug candidates aimed at the biofilm-associated protein (BAP) in Staphylococcus aureus: An in-silico investigation
George Priya Doss C, Mangesh R, Sree Haryini and Mohanraj Gopikrishnan

Über Autor(innen)

Donev, Rossen
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.