Munir, M: Avian Innate Immunity and its Perturbation

1. Auflage 2021
ISBN: 978-3-319-42341-8
Verlag: Springer-Verlag GmbH

Buch, Englisch, 240 Seiten, Book, Format (B × H): 155 mm x 235 mm

This book assembles, critically analyses and brings forward our current understanding on avian innate immunity and its modulations by different viral immune modulators. Birds are one of the most abundant and diverse classes of living being in the universe, which play fundamental and decisive roles in maintaining ecosystem and biodiversity. Both at the standpoints of anatomy and physiology, avian species are unique organisms with assorted characteristics. Due to these features, avian species are excellent model animals for behavioural and pathological studies. Moreover, some avian species such as chicken, ducks and turkeys are important and economical source of meat, and are kept as poultry species. At one end, these poultry birds are meeting ever-increasing demand of the food security while at the other side these are major concern for public health. This book summarizes our knowledge on responses of avian species to viruses, the molecular mechanisms and comparative functional dynamics in diverse avian species. Avian Innate immunity is special, for instance in interferon (IFN) related pathways significant evolutionary adaptations have been reported in chicken, which make chicken interferon system both structurally and functionally unique. An aspect of chicken IFN system gaining attention is the IFN-induced proteins with tetratricopeptide repeats (IFIT) which regulates the pattern recognition, the JAK-STAT signalling and the protein translation. Despite the fact that chicken responds potently to several viruses, it contains only IFIT5 in contrast to mammals, which have IFIT1, IFIT2, IFIT3 and IFIT5 genes. These are only few examples of chicken genome diversity in IFN pathways and such genetics and functional differences are common not only in chicken but also in other avian species. This book will help you to grasp avian innate immunity and its comparative immunogenetics, which is essential for understanding the evolution of birds in general, as well as the dynamics of avian species in responding to viruses and emerging pathogens.

Zielgruppe

Research

Autoren/Hrsg.

Munir, Muhammad

Fachgebiete

• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tierphysiologie
• Medizin | Veterinärmedizin Veterinärmedizin Veterinärmedizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
• Naturwissenschaften Biowissenschaften Virologie

Inhaltsverzeichnis

Introduction and Current Trends in Avian Innate Immunity.- Anatomy, Development, Structure, and Physiology of Avian Innate Immune Organs.- Avian Innate Immunity: What is Special about it?.- Components of Avian Innate Immunity and their Interlinked Molecular Networking.- Avian Interferons and their Receptors.- Avian Toll Like Receptors and Interferon Signalling.- Avian Cytokine, Chemokines and Associated Innate Immune Signalling.- Specificity and Genetics of Avian Innate Immune Responses to Viruses.- Integrated and Systemic Establishment of Antiviral Immunity.- Immune Evasion by Avian viruses.- Modulation of Innate Immunity by micrRNAs and other small non-coding RNA.- Exploitation of Viral Immune Modulation for Intervention Strategies.- Resource for Avian Innate Immunity Research: AvianBase, Comparative Immunogenetics and Reagents.- Avian Innate Immune System: What is Missing and What we are Unable to Find?.- Functional and Advanced Genomics Approaches in Studying Avian Innate Immunity.- Conclusions and Future of Avian Innate Immunity.