The Pancreatic Tumor Microenvironment

Systems Biology of Stroma-Microbiome Interactions for Precision Therapy
Erscheinungsjahr 2027
ISBN: 978-0-443-51742-6
Verlag: Elsevier Science

Buch, Englisch, 220 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 449 g

The Pancreatic Tumor Microenvironment: Systems Biology of Stroma–Microbiome Interactions for Precision Therapy unites leading experts to integrate stromal biology and microbiome science into a single, translational roadmap for pancreatic cancer. It frames tumor progression and treatment resistance as emergent properties of an ecosystem, not isolated cells. The book surveys the composition and heterogeneity of the tumor microenvironment; cancer associated fibroblast plasticity; extracellular matrix and signaling dynamics; immune suppression; metabolic and hypoxic reprogramming; and gut/tumor associated microbiomes. Methodological chapters highlight single cell, spatial and multi omics approaches, experimental models, biomarkers, and clinical trial design, culminating in combination strategies and future directions. Readers gain a mechanistic, systems level synthesis that clarifies conflicting literature, prioritizes targets, and bridges basic, translational, and clinical domains—accelerating precision oncology and informing study design, patient stratification, and therapeutic combinations.

Autoren/Hrsg.

Nagaraju, Ganji Purnachandra

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

1. Unmet Needs and Clinical Difficulties in Pancreatic Cancer
2. Composition, Heterogeneity, and Function of the Pancreatic Cancer Microenvironment
3. The Development of Pancreatic Cancer Stromal Targeting: From Depletion to Reprogramming
4. Functional Subtypes and Cancer Associated Fibroblast Plasticity in Pancreatic Cancer
5. Signaling and Extracellular Matrix Remodelling in Pancreatic Cancer
6. Immune Suppression and Stromal–Immune Crosstalk in Pancreatic Cancer
7. Pancreatic Cancer Stroma Metabolic and Hypoxic Reprogramming
8. The Microbiome Associated with the Gut and Tumor in the Development and Progression of Pancreatic Cancer
9. Interactions between the Microbiome, Immune System, and Stroma in Pancreatic Cancer
10. Modulating the Microbiome Therapeutically in Pancreatic Cancer
11. Investigating Pancreatic Cancer Stroma and Microbiome Interactions through Experimental Models
12. Pancreatic Cancer Research Using Single Cell, Spatial, and Multi Omics Methods
13. Clinical Trial Design, Patient Stratification, and Biomarkers
14. Combination Treatments for the Microbiome, Stroma, and Tumor Cells
15. Conclusion and Prospects for Reprogramming the Pancreatic Cancer Microenvironment

Über Autor(innen)

Nagaraju, Ganji Purnachandra
Dr. Nagaraju obtained his MSc and his PhD, both in Biotechnology, from Sri Venkateswara University in Tirupati, Andhra Pradesh, India. He received his DSc from Berhampur University in Berhampur, Odisha, India. Dr. Nagaraju’s research focuses on translational projects related to gastrointestinal malignancies. He has published over 100 research papers in highly reputed international journals and has presented more than 50 abstracts at various national and international conferences. Dr. Nagaraju is author and editor of several published books for Elsevier and Springer Nature. He serves as editorial board member of several internationally recognized academic journals. Dr. Nagaraju has received several international awards including FAACC. He also holds memberships with the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), The Science Advisory Board, The RNA Society, The American Association for Clinical Chemistry (AACC) and the American Association of Cancer Research (AACR).