Supramolecular Synthons in Crystal Engineering of Pharmaceutical Properties

1. Auflage 2026
ISBN: 978-1-032-19618-3
Verlag: Taylor & Francis Ltd

Buch, Englisch, 198 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 289 g

Reihe: xx xx

This comprehensive resource skillfully consolidates crystal engineering, the design of organic solids, and supramolecular synthons (i.e., structural hydrogen bond units) to achieve desired pharmaceutical properties, including solubility, dissolution, bioavailability, permeability, particle size, tableting, hydration, and mechanical strength. Covering 30 years of crystal engineering developments and pharmaceutical applications, this book will be a single and complete resource for supramolecular and structural chemists, the crystal engineering community, pharmaceutical scientists, and industrial researchers.

Key Features

- Covers the fundamentals of crystal engineering and supramolecular synthons.

- Details the challenges of low solubility and low permeability facing oral drug formulations.

- Explains how heterosynthons provide a rational approach to address and implement solutions.

- Provides case studies from academic and industrial labs to walk the reader through the actual steps.

- Explores developments in the scale up and manufacture of crystal forms in pharmaceutical industry.

Zielgruppe

Academic, Postgraduate, Professional Practice & Development, Professional Reference, and Professional Training

Autoren/Hrsg.

Nangia, Ashwini K.

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie

Über Autor(innen)

Ashwini Nangia (born 1960) is a senior professor of chemistry at the University of Hyderabad, India. He completed his MSc from Indian Institute of Technology Kanpur (1983) and PhD from Yale University (1988). He joined the University of Hyderabad in 1989 and was promoted to professor in 2002 and to senior professor in 2019. His research interests in crystal engineering include polymorphs, cocrystals, salts, eutectics, and amorphous forms of drugs and pharmaceuticals. He has authored more than 350 research publications, with over 18,000 citations and an h-index of 70. He is a fellow of the three premier National Science Academies of India and Royal Society of Chemistry, London. He is a recipient of the prestigious JC Bose National Fellowship. He was director of Council of Scientific and Industrial Research–National Chemical Laboratory, Pune from March 2016 to November 2020, during which time he diversified his interests to flow chemistry and process intensification in crystallization.