Tyrosine Hydroxylase

1. Auflage 1993
ISBN: 978-90-6764-154-8
Verlag: CRC Press

Buch, Englisch, 312 Seiten, Format (B × H): 156 mm x 235 mm, Gewicht: 703 g

Tyrosine hydroxylase is the rate-limiting enzyme in the biosynthesis of catecholamines. Since the discovery of this enzyme by Dr. Toshiharu Nagatsu, the enzyme has been intensively studied in relation to both its physiological function in the brain and brain disorders. Especially the successful application of L-DOPA therapy for Parkinson's disease suggests that this enzyme should have a primary role in the progress of this disease.

As a tribute to Dr. Toshiharu Nagatsu, this book presents an overview of research on this important enzyme, from molecular to clinical aspects. The book also includes the latest results on functional and clinical aspects of the enzyme. It provides as insight in how the enzymatic and biochemical study of this monooxygenase has led to the understanding of many diseases such as Parkinson's disease, stress and emotional disorders.

Zielgruppe

This book will be of interest to researchers in the field of neurochemistry, molecular biology, psycho- and neuropharmacology, neurology and psychiatry.

Autoren/Hrsg.

Naoi

Parvez, Hasan

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Neuropharmakologie, Psychopharmakologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Psychiatrie, Sozialpsychiatrie, Suchttherapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

EDITORIAL
Toshiharu Nagatsu -- A tribute on his 60th birthday
TYROSINE HYDROXYLASE: ITS PROPERTIES AND THE REGULATION OF THE ACTIVITY
Tyrosine Hydroxylase: Historical reflections
T. Nagatsu
Tyrosine Hydroxylase and factors influencing its activity
S. Udenfriend
The influence of nerve growth factor on the level and activity of Tyrosine Hydroxylase
G. Guroff
Allosteric regulation of Tyrosine Hydroxylase activity by its cofactor tetrahydrobiopterin
M. Naoi, M. Minami, W. Maruyama and H. Parvez
Non-catecholaminergic neuronal expression of human Tyrosine Hydroxylase in the brain of transgenic mice with special reference to aromatic L-amino acid decarboxylase
I. Nagatsu, K. Yamada, N. Karasawa, N. Kaneda, T. Sasaoka, K. Kobayashi, K. Fujita and T. Nagatsu
Regulation of Tyrosine Hydroxylase by adenosine derivatives in adrenal chromaffin cells; long-term induction of gene expression and short-term modulation of enzyme activity
Y. Kuroda, K. Muramoto and K. Kumakura
Amine synthesizing enzymes, peptides, growth factors and oncogene products in midgut carcinoid tumours and pheochromocytomas in tissue culture
H. Ahlman, A. Dahlström, M. Goldstein, S. Jansson, A. McRae, O. Nilsson and B. Wängberg
Developmental changes in Tyrosine Hydroxylase in periphery
H. Kuzuya
Enzyme immunoassay of Tyrosine Hydroxylase
M. Mogi and M. Harada
Monitoring of Tyrosine Hydroxylase activity in conscious rat striatum with a microdialysis
T. Kato, S. Hisamatsu and M. Xu
Purification of Tyrosine Hydroxylase
K. Kojima
TYROSINE HYDROXYLASE: ITS MOLECULAR STUDIES
Progress in Tyrosine Hydroxylase gene research
T.H. Joh
Multiplicity of human cDNAs of Tyrosine Hydroxylase
K.L. O'Malley
The human Tyrosine Hydroxylase gene
T. Nagatsu, N. Kaneda, K. Kobayashi, H. Ichinose, T. Sasaoka, K. Kiuchi, K. Fujita and Y. Kurosawa
TYROSINE HYDROXYLASE: ITS INVOLVEMENT TO DISEASES
Clinical evaluation of Tyrosine Hydroxylase activity in brain and peripheral organs
I.J. Kopin
Decrease of Tyrosine Hydroxylase activity and understanding of Parkinson's disease
H. Narabayashi
Tyrosine Hydroxylase in Parkinson's disease
W.-D. Rausch and P. Riederer
Biogenic amines in cerebral ischemia and trauma
M. Spatz, H.M. Pappius and B.B. Mrsulja
Stress-induced changes in Tyrosine Hydroxylase and other catecholamine biosynthetic enzymes
R. Kvetnansky and E.L. Sabban
Tyrosine Hydroxylase in nigrostriatum and hypothalamus: Linkage to the cardiovascular system
N. Alexander
Hypertension in rats fed a low calcium diet: Roles of catecholamine synthesis and secretion
A. Togari