Navakauskas / Borutinskaite / Matuzevicius Epigenetics and Proteomics of Leukemia

A Synergy of Experimental Biology and Computational Informatics
1. Auflage 2021
ISBN: 978-3-030-68707-6
Verlag: Springer, Berlin

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Beschreibung

This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy.

Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.

Autoren

Autoren

Navakauskiene, Ruta

Navakauskiene, Ruta

Matuzevicius, Dalius

Navakauskas, Dalius

Navakauskiene, Ruta

Borutinskaite, Veronika

Über den Autor

Navakauskiene, Ruta
Ruta NAVAKAUSKIEN , Dr. Prof.Department of Molecular Cell Biology, Institute of Biochemistry, Life Sciences Center, Vilnius University, Sauletekio av. 7, LT-10257 Vilnius, Lithuania
Dalius NAVAKAUSKAS, Dr. Prof.Department of Electronic Systems, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko st. 41-426, LT-03227 Vilnius, Lithuania
Veronika BORUTINSKAIT , Dr.Department of Molecular Cell Biology, Institute of Biochemistry, Life Sciences Center, Vilnius University, Sauletekio av. 7, LT-10257 Vilnius, Lithuania
Dalius MATUZEVICIUS, Dr. Assoc. Prof.Department of Electronic Systems, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko st. 41-413, LT-03227 Vilnius, Lithuania

Inhaltsverzeichnis

Overview / Introduction
Section I: Epigenetics in LeukemiaChapter 1: Genetic and Epigenetic Alterations in LeukemiaChapter 2: Epigenetic Modifiers and Their Inhibitors in Leukemia TreatmentChapter 3: Chromatin Remodeling during Leukemia Cell Proliferation and DifferentiationDNA Methylation and Epigenetic RegulationChromatin Functional Regulation by Histone ModificationChapter 4: Approaches to Epigenetic Treatment of Leukemia
Section II: Proteomics in LeukemiaChapter 5: Proteome in Leukemic vs. Differentiated Leukemia CellsChapter 6: Protein Phosphorylation in LeukemiaChapter 7: Computational Methods for Proteome Analysis2DE Fractionation and VisualizationProteomic Data ProcessingProteomic Data AnalysisImage Acquisition and Data Analysis
Section III: Protein Localization in LeukemiaChapter 8: Protein Translocation into the Nucleus during Leukemia Cell DifferentiationChapter 9: Protein Visualization in Leukemic CellsChapter 10: Computational Methods for Protein Localization EstimationFluorescent Image ProcessingFluorescent Image Acquisition and Analysis
Section IV: Future Therapy in Leukemia

Zielgruppe

Research

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