O Tollefsbol | Personalized Epigenetics | Buch | 978-0-12-420135-4 | sack.de

Buch, Englisch, 610 Seiten, Format (B × H): 156 mm x 236 mm, Gewicht: 1097 g

O Tollefsbol

Personalized Epigenetics


Erscheinungsjahr 2015
ISBN: 978-0-12-420135-4
Verlag: Elsevier Science

Buch, Englisch, 610 Seiten, Format (B × H): 156 mm x 236 mm, Gewicht: 1097 g

ISBN: 978-0-12-420135-4
Verlag: Elsevier Science


Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy.

The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.

Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.

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Zielgruppe


<p>Advanced undergraduate students, graduate students, health care professionals, university researchers, pharmaceutical companies interested in drug development and biotechnology companies. This book could also serve as a core textbook for advanced university or professional school courses with a focus on genetic and/or human diseases</p>


Autoren/Hrsg.


Weitere Infos & Material


Section I: Overview

1. Epigenetics of Personalized Medicine

Section II: Epigenetic Variations Among Individuals

2. Inter-individual Variability of DNA Methylation

3. Differences in Histone Modifications Between Individuals

4. Individual Noncoding RNA Variations: Their Role in Shaping and Maintaining the Epigenetic Landscape

5. Personalized Epigenetics: Analysis and Interpretation of DNA Methylation Variation

Section III: Bioinformatics of Personalized Epigenetics

6. Computational Methods in Epigenetics

Section IV: Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine

7. Epigenetic Biomarkers in Personalized Medicine

8. Epigenetic 'Fingerprint'

9. Epigenetics of Personalized Toxicology

Section V: Environmental Personalized Epigenetics

10. Environmental Contaminants and their Impacts on the Epigenome

11. Nutriepigenomics: Personalized Nutrition Meets Epigenetics

Section VI. Pharmacology and Drug Development of Personalized Epigenetics

12. Personalized Pharmacoepigenomics

13. Personalized Medicine and Epigenetic Drug Development

Section VII: Personalized Epigenetics of Disorders and Disease Management

14. Epigenetics and Personalized Pain Management

15. Understanding Inter-individual Epigenetic Variations in Obesity and its Management

16. Epigenetic Modification of miRNAs in Cancer

17. Managing Autoimmune Disorders Through Personalized Epigenetic Approaches

18. Cardiovascular Diseases and Personalized Epigenetics

Section VIII: Challenges and Future Directions

19. Future Challenges and Prospects for Personalized Epigenetics



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