Genomic Surveillance and Pandemic Preparedness

Erscheinungsjahr 2023
ISBN: 978-0-443-18769-8
Verlag: Elsevier Science Publishing Co Inc

Buch, Englisch, 450 Seiten, Format (B × H): 235 mm x 190 mm, Gewicht: 884 g

Genomic Surveillance and Pandemic Preparedness offers practical, in-depth instruction in where, how, and why genomic surveillance may be applied. Drawing heavily from the learnings during the COVID-19 pandemic, this book covers different aspects of microbes with a focus on viral genome sequencing and analysis, implementation and inference of genomic surveillance, and global data sharing best practices for future pandemic preparedness. Here, more than a dozen international authors consider host and pathogen genome interaction, population-level prevalence, individual disease susceptibility and gene protection, pathogen mutation evolutionary dynamics, RNA modulation of infection, pathogen diversity, and the role of coinfections and comorbidities in disease severity. A wide range of examples, from bacterial pathogens to fungal and viral infections, with an emphasis on recent COVID-19 analysis, are discussed. Finally, the authors provide step-by-step instruction in experimental and computational approaches for genomic surveillance, including nucleic acid isolation, sequencing library preparation, functional sequencing analysis, and bioinformatics pipelines. Throughout this book, importance is placed on inference-moving from genomic sequencing to meaningful genomic surveillance that bolsters pandemic preparedness.

Autoren/Hrsg.

Pandey, Rajesh

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

Section A: Pathogens and Host: Genomics perspective 1. Population level differences in COVID-19 prevalence, severity, and clinical outcome 2. Host genetics in disease susceptibility and protection 3. RNA as modulators infection outcome: Potential usage for genomic surveillance Section B: Pathogen Diversity 4. Genomic surveillance of bacterial pathogens: expanding horizons Section C: Cofactors in addition to pathogen 5. Host immune responses in COVID-19: implication for preexisting chronic systemic inflammation 6. Role of co-infections in modulating disease severities and clinical phenotypes 7. Wastewater surveillance: a quick guide to check community health Section D: Future pandemic preparedness 8. Experimental repertoire to elucidate the functional landscape of hostepathogen interactome 9. Computational means to understand and elucidate hostepathogen interaction and outcome 10. Genomic surveillance system and technologies Section E: Roadmap ahead 11. Interactions shaping the Interactome: genome surveillance inclusive of host-pathogen 12. Health informatics and data science for pandemic preparedness 13. Harsh environmental stressors of high altitude on pathogens susceptibility 14. Implications of antibiotics and antimicrobial resistance development during COVID-19: questing genomic surveillance for a balancing act

Über Autor(innen)

Pandey, Rajesh
In earning his PhD, Dr. Rajesh Pandey used a combination of functional genomics and computational tools to elucidate the role of noncoding RNA during stress response. This convinced him of the potential of the RNA regulatory repertoire and its role in shaping human evolution, health, disease states, diagnosis, prognosis, and therapeutics. Subsequently, he has employed diverse genomic toolkits to understand and explore RNA-level regulation at different hierarchies, encompassing human, mouse, plant, fungi, bacteria genomics, and metagenomics. In addition to his research work, Dr. Pandey has been a tutor at many workshops on applications of NGS technologies, and has published peer reviewed papers in such journals as Genome Biology; Genome Biology and Evolution; Nucleic Acids Research; Journal of Cell Science; PLOS Genetics; Frontiers in Microbiology; Scientific Reports; Molecular Cell; and Clinical Genetics. His future interest lies in investigating the role of noncoding RNA in modulating human phenotypic variation and its impact on health and disease spectrum.