Polymers for Oral Drug Delivery Technologies

Erscheinungsjahr 2024
ISBN: 978-0-443-13774-7
Verlag: Elsevier Science

Buch, Englisch, 854 Seiten, Format (B × H): 150 mm x 229 mm, Gewicht: 1297 g

Polymers for Oral Drug Delivery Technologies covers the fundamentals of oral drug delivery and various aspects of polymer technology in oral drug delivery, from classification and synthesis, to applications and regulatory factors. It presents the oral delivery?of therapeutics for treating a number of diseases, along with the challenges of oral drug administration to assure a predictive and reproducible pharmacokinetic profile of active pharmaceutical ingredients (API).

Polymers play an important role to achieve the targeted release profile consistently of an API in vivo by various functionalities like drug protection from gastric juice, fast release and supersaturation or release within a targeted area of the GI tract.

Autoren/Hrsg.

Parambath, Anilkumar

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Technologie der Kunststoffe und Polymere
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Technologie der Textilverarbeitung und Faserverarbeitung
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde
• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie

Inhaltsverzeichnis

Section A. Fundamentals of Oral Drug Delivery
1. GI tract environment (e.g. gastric juice, bile salts, pH, amylases, proteases etc.)
2. GI tract motility and transport
3. Drug absorption and pre-systemic metabolism and PK modelling
4. In vitro dissolution and predictive release testing
5. Principle characteristics and specification of pharmaceutical polymers
6. Regulatory Aspects of Polymers Used and new polymers for Oral Medication

Section B. Role Polymer Technology in Oral Drug Delivery
7. Classes/types of polymers used in oral delivery (natural, semi-synthetic, synthetic), their chemical structure and general functionalities
8. Role of polymers in Tableting
9. Capsule forming Polymers
10. Dry and wet Granulation
11. Matrix formers
12. Functional Polymer Coatings (IR, easy to swallow, enteric etc.)
13. Amorphous systems (e.g. HME, SD)
14. Micro/Nanoparticles
15. Taste masking polymers
16. Polymers in Orally disintegrating tablets and Orally dissolving films
17. Additive manufacturing (3D printing)
18. Mucoadhesive forms
19. Gastro-retentive forms
20. Polymer blends and additives

Über Autor(innen)

Parambath, Anilkumar
Dr Anilkumar Parambath is Senior R&D Manager of YTY Group, Indorama Corp., Perak, Malaysia. Prior to this, he was R&D Manager, Science & Technology at Unilever (2021-2024); Senior Manager and Head of Capsules Product R&D, ACG Capsules, Mumbai, India (2018-2021) and Principal Investigator for Performance and Specialty Materials at Syngene International Ltd, Bangalore India (2017-2018), where he worked on developing various elastomers, silicones, acrylics and other polymers for biomedical applications. He completed his PhD in Chemistry (Polymer Science) at the University of Kerala, India, and spent 7 years conducting post-doctoral research at Clemson University, USA, French atomic Energy Commission (CEA), France, and the University of British Columbia, Canada. HIs expertise is in polymer science, materials science, green chemistry, nanotechnology, nanomedicine, and biomaterials science. Dr. Parambath has edited three books on polymer biomaterials in drug delivery applications, including two with Elsevier, and has published many books chapters and journal articles. He has two patents to his name. In 2024, he was recognized by the American Chemical Society (ACS) as a Sustainability Star.