The Liver

Oxidative Stress and Dietary Antioxidants
Erscheinungsjahr 2018
ISBN: 978-0-12-803951-9
Verlag: Elsevier Science

Buch, Englisch, 368 Seiten, Format (B × H): 216 mm x 278 mm, Gewicht: 1020 g

The Liver: Oxidative Stress and Dietary Antioxidants takes a novel approach to the science of oxidative stress in liver disease by recognizing that diseases are multifactorial and oxidative stress is a single component. It highlights oxidative stress in relation to other processes, such as apoptosis, cell signaling and receptor mediated responses, and includes the therapeutic usage of natural antioxidants in the diet and food matrix, along with coverage of pharmacological and natural agents designed to counteract oxidative stress. Written for research scientists, gastroenterologists, food scientists, hepatologists and physicians, this trans-disciplinary guide will help advance medical sciences and enable new preventative and treatment strategies.

Autoren/Hrsg.

Patel, Vinood

Rajendram, Rajkumar

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Hepatologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Gastroentereologie, Proktologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik

Inhaltsverzeichnis

Oxidative Stress and the Liver 1. Oxidative stress in hepatitis C infection 2. Peroxidases and oxidative stress in fatty livers 3. Alterations in nucleocytoplasmic localization of the methionine cycle induced by oxidative stress during liver disease 4. Oxidative stress in iron toxicity of the liver5. Cardiac glycosides and oxidative stress in liver cancer6. Acetaldehyde effects on cellular redox state. 7. The role of glyoxalase-I in oxidant stress of liver damage8. Antioxidants 1 Reactive oxygen and nitrogen species and liver ischemia-reperfusion injury: an overview

Antioxidants and the Liver9. Antioxidants 2 Reactive oxygen and nitrogen species and liver ischemia-reperfusion injury: role of arginine and glutamine 10. Antioxidants 2 Reactive oxygen and nitrogen species and liver ischemia-reperfusion injury: role of lipoic acid11. Oxidative stress as crucial factor in liver disease: Potential Therapeutic effect of Antioxidants 12. L-NAME as a synthetic antioxidant in liver injury 13. Vitamin C, oxidative stress and liver protection 14. Lycopene, liver protection and oxidative stress 15. Vitamin E protection against hyperthyroidism-induced liver oxidative stress16. Citric acid an antioxidant in liver 17. Resveratrol and protection in hepatic steatosis: antioxidant effects 18. Astaxanthin, a marine carotenoid against hepatic oxidative stress: A systematic review. 19. Effects of melatonin as an antioxidant in liver 20. Antioxidant role of the Mayan fruit canistel (Pouteria campechiana) in liver protection21. Endogenous mitochondrial aldehyde dehydrogenase-2 as an antioxidant in liver22. Comparing antioxidants in liver disease: L-carnitine, N-acetylcysteine and genistein 23. Coenzyme Q10, liver protection and oxidative stress 24. Carnosine as a putative antioxidant in usage against liver disease25. Dioscin as a natural saponin and protection in oxidative stress in hepatic fibrosis26. Gallic acid as a putative antioxidant in usage against liver disease27. Oleuropein as an antioxidant and liver protection28. Garlic and Liver Diseases

Über Autor(innen)

Patel, Vinood
Vinood B. Patel, BSc, PhD, FRSC, is currently Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress in neurological disorders and iron dysregulation in diabetes. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. These books include The Handbook of Nutrition, Diet, and Epigenetics, Branched Chain Amino Acids in Clinical Nutrition, Cancer: Oxidative Stress and Dietary Antioxidants, Toxicology: Oxidative Stress and Dietary Antioxidants, Molecular Nutrition: Vitamins, The Neuroscience of Pain, Cognitive Behavioural Therapy. He is Editor of the ten-volume series Biomarkers in Disease: Methods, Discoveries and Applications

Rajendram, Rajkumar
Dr Rajkumar Rajendram is a clinician-scientist with expertise in internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St Thomas’ Medical School, King’s College London, in 2001, where he received several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram completed specialist training in acute and general medicine in Oxford and subsequently held a Consultant appointment in Acute General Medicine at the John Radcliffe Hospital, Oxford. He also trained in anaesthesia and intensive care in London, including advanced training in regional anaesthesia and intensive care, and subsequently held a Consultant appointment in Intensive Care, Anaesthesia and Peri-operative Medicine at the Royal Free London Hospitals.

His postgraduate training has spanned internal medicine, anaesthesia, intensive care and point-of-care ultrasound (POCUS). He was awarded Fellowship of the Royal College of Anaesthetists in 2009, Fellowship of the Faculty of Intensive Care Medicine in 2013, and the European Diploma in Intensive Care Medicine in 2014. He is a Fellow of both the Royal College of Physicians of Edinburgh and the Royal College of Physicians of London.

Dr Rajendram is currently a Consultant at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, and holds a joint appointment as Associate Professor in the Research Unit, Department of Medical Education, at King Saud bin Abdulaziz University for Health Sciences.

His multidisciplinary clinical background has informed his research interests in nutrition, fluid management and fluid balance in health and disease, particularly in acutely and critically ill patients. His research has also addressed POCUS, COVID-19 phenotypes and nutritional support in illness. Dr Rajendram has contributed extensively to medical research and education and has authored more than 400 textbook chapters, review articles, peer-reviewed papers and conference abstracts.