Buch, Englisch, Band 65.66, 860 Seiten
Reihe: Progress in Drug Research
ISBN: 978-3-7643-8626-9
Verlag: Springer
In molecular biological research, natural products also play an important role as tool compounds in pathway screening and validation of target identification concepts. They provide innovative opportunities in drug discovery, leading to a detailed understanding of biological pathways and revealing the functions of involved enzymes or receptors.
This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
From the contents
Mother nature's gifts to diseases of man: The impact of natural products on anti-infective, anticholestemics and anticancer drug discovery.- Drug discovery and development with plant-derived compounds.- Evolutionary mechanisms underlying secondary metabolite diversity.- Biodiversity, chemical diversity and drug discovery.- High impact technologies for natural products screening.- Virtual screening for the discovery of bioactive natural products.- Strain improvement for production of pharmaceuticals and other microbial metabolites by fermentation.- Nutritional and engineering aspects of microbial process development.- Natural products from plant cell cultures.- Activation of fungal silent gene clusters: An new avenue to drug discovery.- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin.- Application of natural product-inspired diversity-oriented synthesis to drug discovery.
