Principles of Molecular Probe Design and Applications

1. Auflage 2023
ISBN: 978-981-19-5741-3
Verlag: Springer Nature Singapore

Buch, Englisch, 317 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 559 g

This book describes insight mechanisms for designing molecular probes and methods that these agents can be used for medical diagnosis in preclinical animal models via optical, MRI and PET imaging. The book has a wealth of schemes of synthesis and methods deduced from pioneers in the field, making it possible to immerse into real-world molecular imaging. Written for graduate student training and practitioners, this book will serve as a teaching material and/or reference for anyone interested in exploring the power of chemical synthesis of imaging agents.

Zielgruppe

Research

Autoren/Hrsg.

Pham, Wellington

Fachgebiete

• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Naturwissenschaften Physik Quantenphysik Atom- und Molekülphysik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe

Inhaltsverzeichnis

Chapter 1: Overview of the fundamentals of chemistry for molecular probe design.- Chapter 2: Principles for the design of fluorescent dyes.- Chapter 3: Principles for the design of PET probes.- Chapter 4: Principles for the design of MRI probes.- Chapter 5: Solid-phase chemistry.- Chapter 6: Construction of molecular probes and imaging applications

Über Autor(innen)

Wellington Pham received a Ph.D. degree in Medicinal Chemistry from the University of Toledo. His postdoctoral training focused on PET chemistry at The Crump Institute for Molecular Imaging, UCLA Medical School, followed by two postdoctoral trainings in molecular imaging at the Center of Molecular Imaging Research and the Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School. Currently, he is Professor of Radiology at Vanderbilt University Medical Center and holds joint appointments in the Departments of Biomedical Engineering, Vanderbilt Ingram Cancer Center, and Vanderbilt Brain Institute. He served on several steering committees and conference organizers on molecular imaging and molecular probes and a recipient of the Distinguished Investigator Award of the Academy for Radiology & Biomedical Imaging Research (2019). His research interests include the discovery of biomarkers and imaging probes, combined with delivery technologies dedicated to cancer and Alzheimer’s disease, and he has published nearly 150 publications, including peer-reviewed articles, book chapters, conference abstracts/proceedings, editorials, and patents on these subjects. His research has been funded by NIH, DOD, VA grants, and ADEKA Corporation.