Molecular Mechanisms of Cell Differentiation in Gonad Development

1. Auflage 2016
ISBN: 978-3-319-31971-1
Verlag: Springer International Publishing

Buch, Englisch, 434 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 7922 g

Reihe: Results and Problems in Cell Differentiation

This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions.

The individual chapters review the origin and differentiation of the somatic cells of the genital ridges; the formation and migration of primordial germ cells in mouse and man; the gonadal supporting cell lineage and mammalian sex determination; differentiation of Sertoli and granulosa cells; mesonephric cell migration into the gonads and vascularization; origin and differentiation of androgen-producing cells in the gonads; germ cell commitment to the oogenic versus spermatogenic pathway and the role of retinoic acid; ovarian folliculogenesis; control of oocyte growth and development by intercellular communication within the follicular niche; biology of the Sertoli cell in the fetal, pubertal and adult mammalian testis; mechanisms regulating spermatogonial differentiation; stem cells in mammalian gonads; the role of microRNAs in cell differentiation during gonad development; human sex development and its disorders; as well as methods for the study of gonadal development.

Zielgruppe

Research

Autoren/Hrsg.

Piprek, Rafal P.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Reproduktionsmedizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

Early Development of the Gonads – Origin and Differentiation of the Somatic Cells of the Genital Ridges.- The formation and migration of primordial germ cells in mouse and man.- The Gonadal Supporting Cell Lineage and Mammalian Sex Determination: the Differentiation of Sertoli and Granulosa Cells.- Mesonephric cell migration into the gonads and vascularization are processes crucial for testis development.- Origin and Differentiation of Androgen-producing Cells in the Gonads.- Germ cell commitment to oogenic versus spermatogenic pathway - the role of retinoic acid.- Ovarian Folliculogenesis.- Control of oocyte growth and development by intercellular communication within the follicular niche.- Biology of the Sertoli cell in the Fetal, Pubertal and Adult Mammalian Testis.- Mechanisms Regulating Spermatogonial Differentiation.- Stem cells in mammalian gonads.- A Role of microRNAs in Cell Differentiation during Gonad Development.- The Battle of the Sexes: Human Sex Development and its Disorders.- Methods for the study of gonadal development.