Buch, Englisch, 478 Seiten, Format (B × H): 173 mm x 248 mm, Gewicht: 1079 g
Recent Advances in Molecular and Cellular Pathogenesis and Treatment
Buch, Englisch, 478 Seiten, Format (B × H): 173 mm x 248 mm, Gewicht: 1079 g
ISBN: 978-0-19-850878-6
Verlag: Oxford University Press
Lysosomal storage diseases are inherited metabolic disorders characterized by severe pathology, typically involving the brain. Although individually rare, they collectively represent a significant group of diseases that primarily present in early infancy or childhood. In recent years considerable progress has been made in understanding the molecular mechanisms that lead to disordered function of the lysosomal system and to lysosomal storage. Unravelling the basis for these diseases is providing unique insight into the normal biology of cells and pointing the way to the development of therapeutic strategies for their treatment.
Lysosomal Disorders of Brain details recent advances in the molecular and cellular pathologies of these diseases and in the development of effective therapies. After an overview of the biology of the endosomal-lysosomal system and the types of diseases resulting from defects in this system, the book describes in detail the molecular mechanisms of storage, model systems and pathophysiological mechanisms, and finally, new advances toward treatment. With each chapter written by leading experts in their field, this book will be valuable for scientists and clinicians in helping them understand the role of lysosomes in normal cells and mechanisms underlying these disorders, how they can be diagnosed, and the treatment options that are currently available.
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Innere Medizin
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
Weitere Infos & Material
- Foreword
- Preface
- Prologue
- Section I: Overview of Lysosomes and Storage Diseases
- 1: Maxfield and Mukherjee: The endosomal-lysosomal system
- 2: Platt and Walkley: Lysosomal defects and storage
- 3: Wraith: Clinical aspects and diagnosis
- Section II: Molecular Mechanisms of Storage
- 4: Winchester: Primary defects in lysosomal enzymes
- 5: von Figura et al: Defects in lysosomal enzyme modification for catalytic activity
- 6: Hasilik and Lemansky: Defects in lysosomal enzyme trafficking
- 7: d'Azzo: Defects in lysosomal enzyme protection: galactosialidosis
- 8: Sandhoff and Kolter: Defects in activator proteins and other soluble proteins of the lysosome
- 9: Ioannou: Defects in transmembrane proteins
- Section III: Model Systems and Pathophysiological Mechanisms
- 10: Pearce: Simple non-mammalian systems
- 11: Hopwood et al: Spontaneous and engineered mammalian storage disease models
- 12: Walkley: Pathogenic cascades and brain dysfunction
- Section IV: Treatment of Storage Diseases
- 13: Neufeld: Enzyme replacement therapy
- 14: Dobrenis: Cell-mediated delivery systems
- 15: Platt and Butters: Inhibition of substrate synthesis: a pharmacological approach for glycosphingolipid storage disease therapy
- 16: Sands: Gene therapy
