Gene Therapy of Autoimmune Disease

1. Auflage. Softcover version of original hardcover Auflage 2005
ISBN: 978-1-4419-3427-7
Verlag: Springer US

Buch, Englisch, 149 Seiten, Previously published in hardcover, Format (B × H): 152 mm x 229 mm, Gewicht: 226 g

Reihe: Medical Intelligence Unit

Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs.

comprehensivelyreviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Prud'homme, Gerald J.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Allergologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Gentherapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

Gene Therapy Approaches for Autoimmune Diseases of the Central Nervous System and Other Tissues.- Gene Therapeutics in Autoimmune Diabetes.- Immunogene Therapy with Nonviral Vectors.- Targeting Antigen-Specific T Cells for Gene Therapy of Autoimmune Disease.- Therapeutic Gene Transfer for Rheumatoid Arthritis.- Gene Therapy-Based Approach for Immune Tolerance Induction Using Recombinant Immunoglobulin Carriers.- DNA Vaccination against Autoimmune Diseases.