Standardizing Animals for American Biomedical Research, 1900-1955
Buch, Englisch, 312 Seiten, Format (B × H): 161 mm x 240 mm, Gewicht: 661 g
ISBN: 978-0-691-01636-8
Verlag: Princeton University Press
Making Mice blends scientific biography, institutional history, and cultural history to show how genetically standardized mice came to play a central role in contemporary American biomedical research. Karen Rader introduces us to mouse "fanciers" who bred mice for different characteristics, to scientific entrepreneurs like geneticist C. C. Little, and to the emerging structures of modern biomedical research centered around the National Institutes of Health. Throughout Making Mice, Rader explains how the story of mouse research illuminates our understanding of key issues in the history of science such as the role of model organisms in furthering scientific thought. Ultimately, genetically standardized mice became icons of standardization in biomedicine by successfully negotiating the tension between the natural and the man-made in experimental practice. This book will become a landmark work for its understanding of the cultural and institutional origins of modern biomedical research. It will appeal not only to historians of science but also to biologists and medical researchers.
Autoren/Hrsg.
Fachgebiete
- Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
- Medizin | Veterinärmedizin Veterinärmedizin Veterinärmedizin: Labortiere, Tierversuche
- Interdisziplinäres Wissenschaften Wissenschaften: Allgemeines Geschichte der Human- und Sozialwissenschaften
- Geisteswissenschaften Geschichtswissenschaft Geschichtliche Themen Wissenschafts- und Universitätsgeschichte
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
- Interdisziplinäres Wissenschaften Wissenschaften: Allgemeines Geschichte der Naturwissenschaften, Formalen Wissenschaften & Technik
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
- Naturwissenschaften Biowissenschaften Biowissenschaften
Weitere Infos & Material
Illustrations ix
Acknowledgments xiii
Abbreviations xvii
INTRODUCTION: Why Mice? 1
CHAPTER ONE: Mice, Medicine, and Genetics: From Pet Rodents to Research Materials (1900-21) 25
CHAPTER TWO: Experiment and Change: Institutionalizing Inbred Mice (1922-30) 59
CHAPTER THREE: Mice for Sale: Commodifying Research Animals (1930-33) 97
CHAPTER FOUR: A New Deal for Mice: Biomedicine as Big Science (1933-40) 135
CHAPTER FIVE: R X Mouse: JAX Mice in Cancer Research (1938-55) 175
CHAPTER SIX: Mouse Genetics as Public Policy: Radiation Risk in Cold War America (1946-56) 221
EPILOGUE: Animals and the New Biology: Oncomouse and Beyond 251
Bibliography 269
Index 293
