Biopolymer-Based Therapeutics for Inflammation Modulation in Wound Care

Erscheinungsjahr 2027
ISBN: 978-0-443-52627-5
Verlag: Elsevier Science

Buch, Englisch, 300 Seiten, Format (B × H): 191 mm x 235 mm

Biopolymer-Based Therapeutics for Inflammation Modulation in Wound Care presents a comprehensive, biomarker-driven exploration of how natural and engineered biopolymers are transforming the management of acute, chronic, and non-healing wounds. Positioned at the intersection of biomaterials science, pharmaceutical innovation, and clinical practice, the book addresses one of the central challenges in wound care: persistent inflammation that delays tissue repair and regeneration. Beginning with the biological and clinical foundations of wound healing, the book systematically examines inflammatory pathways and key biomarkers such as TNF-a, IL-6, ROS, and VEGF.

It then advances into in-depth coverage of natural biopolymers—including collagen, chitosan, hyaluronic acid, silk-derived polymers, and marine polysaccharides—and their roles in immune modulation, macrophage polarization, and redox balance. Dedicated sections explore advanced delivery platforms such as nanofibers, smart hydrogels, nanozymes, and stimuli-responsive dressings, alongside emerging precision technologies including 3D printing and AI-guided material design. With a strong translational focus, the book bridges laboratory research and real-world application, addressing regulatory pathways, manufacturing scalability, and commercialization challenges.

Autoren/Hrsg.

Raina, Neha

Mishra, Neeraj

Gupta, Madhu

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

Section I. Biological and Clinical Foundations
1. Physiology of Normal Wound Healing
2. Pathophysiology of Impaired and Chronic Wounds: Clinical Perspectives
3. Inflammation Biomarkers and Molecular Drivers of Delayed Healing

Section II. natural Biopolymers as Therapeutic Agents
4. Mechanisms of Natural Biopolymer-Driven Inflammatory Modulation
5. Established Biopolymers in Wound Care: Collagen, Chitosan, and Hyluronic Acid as modulators of Macrophage Polarization
6. Silk Fibroin, Silk Sericin, Keratin, and Chondroitin Sulfate: Roles in Cytokine Regulation and Biomedical Applications
7. Novel Natural Polymers and Hemostatic Agents in Acute and Chronic Wounds
8. Marine-Derived Polymers in Wound Healing Applications: Recent Advances and Future Prospects

III. Advanced Biopolymer Delivery Platforms
9. Biopolymer Dressings, Films, and Nanofiber Systems: Inflammation and ROS Modulation
10. Advanced Anti-Inflammatory Biomaterials: Nanozyme Systems, Catalytic Antioxidants, and Bioactive Nanoparticles
11. Protein-Derived Biomaterials for Redox Modulation and Regenerative Healing: Gelatin, Keratin, and Elastin
12. Stimuli-Responsive smart Biopolymer Dressings for ROS Control in Wound Healing
13. Biopolymer-Based Inflammation Modulation: Clinical Needs, Research Investigations and Regulatory Perspectives

Section IV. Precision Technologies in Wound Biopolymer Design
14. 3D-Printed Biopolmeric Constructs for Personalized Anti-Inflammatory Wound Repair
15. AI-Guided Design and Predictive Modelling of Inflammation modulating Biopolymer Therapeutics

Section V. Translation, Commercialization, and Global Impact
16. Regulatory Pathways, and Approval Frameworks for Biopolymer-Based Anti-inflammatory Therapies
17. Manufacturing Scalability, Clinical Adoption, and Commerical Challenges of Inflammation-Modulating Biopolymers
18. Future Directions: Integrating Biomarkers, Smart Materials, Standardized In-vivo Models and Patient-Centered Outcomes

Über Autor(innen)

Gupta, Madhu
Dr. Madhu Gupta is an Associate Professor at Delhi Pharmaceutical Sciences and Research University, New Delhi. Dr. Gupta’s research experience is drug delivery to nanoformulations for placental extract, regenerative medicine, magical molecule delivery, bioligands for targeting bioactives and drug moiety, biopolymers and green nanotechnology. She is exploring the area of fungal infection, wound healing, herbal delivery and psoriasis. Dr. Gupta has over 17 years academic, administrative and research experience. Dr. Gupta was recognized among the top 2% of scientists globally in the year 2023-24, 2025 list that often comes from data compiled by Stanford University researchers, published in collaboration with Elsevier and other academic databases. She has over 120 research publications to her credit published in journals of high scientific impact and contributed 40 chapters in various renowned books and to several international and national books. She also a PCT patent for effective wound healing therapy and one Indian patent.

Raina, Neha
Dr. Neha Raina has over six years of research experience in the drug delivery field, with a particular focus on wound healing, nanotechnology, and polymer science. She was recognized among the world’s top 2% of scientists in 2025 by Stanford University researchers. Dr. Raina has published original research on wound healing and has several review and research articles currently in communication. She is the editor of two books on wound healing and has authored more than 31 research and review publications in high-impact scientific journals. In addition, she has contributed 10 chapters to internationally and nationally published books. Dr. Raina has collaborated with international researchers at INTI International University (Malaysia) and the University of Brunei Darussalam. Her honors include the Distinguished Researcher Award from DPSRU (2022), along with multiple Best Oral and Best Poster Presentation awards at national conferences.

Mishra, Neeraj
Dr. Neeraj Mishra is Professor and Head of the Department of Pharmaceutics at the Amity Institute of Pharmacy, Gwalior. He has over 20 years of teaching and research experience in pharmaceutics, with particular expertise in novel drug delivery systems, localized and targeted drug delivery, and nanocarrier-based therapeutics for disease. His formulations and controlled delivery approaches are aimed at improving therapeutic outcomes. Dr. Mishra has supervised postgraduate and doctoral research scholars, has contributed widely to academic literature through research publications, books, and book chapters with leading international publishers. He has won several awards including Outstanding Scientist Award, and Distinguished Professor Award. He is associated with innovation in pharmaceutical sciences through patented research contributions. Over the course of his career, he has received several academic and scientific recognitions for his contributions to teaching, and research. He has been recognized internationally for his research impact and scholarly contributions.