Translational Autoimmunity, Volume 1

Etiology of Autoimmune Diseases
Erscheinungsjahr 2021
ISBN: 978-0-12-822564-6
Verlag: Elsevier Science

Buch, Englisch, 390 Seiten, Format (B × H): 190 mm x 234 mm, Gewicht: 794 g

Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions.

Autoren/Hrsg.

Rezaei, Nima

Weitere Mitwirkende

Yazdanpanah, Niloufar

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Infektionskrankheiten
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

1. Introduction on translational autoimmunity: From bench to bedside 2. Autophagy in autoimmunity 3. Immunometabolism and autoimmunity 4. T cell recognition of neo-epitopes in autoimmunity 5. Role of Th1 and Th2 in autoimmunity 6. Role of Th17 cell in tissue inflammation and organ-specific autoimmunity 7. Peptide editing and its modulation in CD4+ T cell immune tolerance 8. Innate lymphoid cells (ILCs) in the immunopathogenesis of autoimmune diseases 9. Autoimmune diseases and the role of toll-like receptor-7 and -9 signaling cascades 10. Association between type III interferons and systemic autoimmune diseases 11. Regulation of immunological tolerance by NF-kB 12. Micro RNA, circular RNA, neutrophils and myeloperoxydases in autoimmune diseases 13. Human leukocyte antigen and autoimmunity 14. HLA-G-mediated immunological tolerance and autoimmunity 15. The immune system and the microbiota: the two sides of mucosal tolerance 16. Role of free radicals in autoimmune disorders 17. Immunological tolerance and autoimmunity 18. Construction of bioscore for sprouting of self-tolerance failure: From analysis of silicosis cases

Über Autor(innen)

Rezaei, Nima
Nima Rezaei, MD, PhD, is Professor of Clinical Immunology and Allergy at Tehran University of Medical Sciences, where he also serves as Associate Dean of International Affairs for the School of Medicine and Director of the Global Academic Program. He is Deputy President of the Research Center for Immunodeficiencies and holds an affiliated research appointment in the Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet, Sweden. He earned his MD from Tehran University of Medical Sciences and his PhD in Clinical Immunology and Human Genetics from the University of Sheffield, United Kingdom. His research addresses primary immunodeficiencies and translational immunology, with recent work extending into computational and AI-based approaches to immune profiling. He is the founder and President of the Universal Scientific Education and Research Network (USERN) and serves as co-editor of the Springer Nature series Advances in Experimental Medicine and Biology.