Rodríguez-Ezpeleta / Hackenberg / Aransay | Bioinformatics for High Throughput Sequencing | Buch | sack.de

Rodríguez-Ezpeleta / Hackenberg / Aransay Bioinformatics for High Throughput Sequencing



2012, 255 Seiten, Kartoniert, Previously published in hardcover, Format (B × H): 154 mm x 238 mm, Gewicht: 415 g
ISBN: 978-1-4899-9876-7
Verlag: Springer, Berlin


Rodríguez-Ezpeleta / Hackenberg / Aransay Bioinformatics for High Throughput Sequencing

Next generation sequencing is revolutionizing molecular biology. Owing to this new technology it is now possible to carry out a panoply of experiments at an unprecedented low cost and high speed. These go from sequencing whole genomes, transcriptomes and small non-coding RNAs to description of methylated regions, identification protein – DNA interaction sites and detection of structural variation. The generation of gigabases of sequence information for each of this huge bandwidth of applications in just a few days makes the development of bioinformatics applications for next generation sequencing data analysis as urgent as challenging.

Zielgruppe


Research

Weitere Infos & Material


Preface.- Introduction.- Overview of Sequencing Technology Platforms.- Applications of High Throughput Sequencing.- Computational Infrastructure and Basic Data Analysis for High-Throughput Sequencing.- Base-Calling for Bioinformaticians.- De Novo Short Read Assembly.- Short Read Mapping.- DNA-Protein Interaction Analysis (ChIP-Seq).- Genome-wide Methylation Maps.- Differential Expression for RNA Sequencing (RNA-seq) Data: Mapping, Summarization, Statistical Analysis and Experimental Design.- MicroRNA Expression Profiling and Discovery.- Dissecting Splicing-Regulatory Network by Integrative Analysis of HITS-CLIP data.- Analysis of Metagenomics Data.- High Throughput Sequencing Data Analysis Software: Current State and Future Developments.- Index.


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