Drama of DNA

Narrative Genomics
Erscheinungsjahr 2014
ISBN: 978-0-19-930935-1
Verlag: Oxford University Press

Buch, Englisch, 240 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 395 g

Through the use of dramatic narratives, The Drama of DNA brings to life the complexities raised by the application of genomic technologies to health care and diagnosis. This creative, pedagogical approach shines a unique light on the ethical, psychosocial, and policy challenges that emerge as comprehensive sequencing of the human genome transitions from research to clinical medicine. Narrative genomics aims to enhance understanding of how we evaluate, process, and share genomic information, and to cultivate a deeper appreciation for difficult decisions encountered by health care professionals, bioethicists, families, and society as this technology reaches the bedside.

This innovative book includes both original genomic plays and theatrical excerpts that illuminate the implications of genomic information and emerging technologies for physicians, scientists, counselors, patients, blood relatives, and society. In addition to the plays, the authors provide an analytical foundation to frame the many challenges that often arise.

Autoren/Hrsg.

Rothenberg, Karen H.

Bush, Lynn Wein

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Evolutionsbiologie
• Sozialwissenschaften Ethnologie | Volkskunde Ethnologie Ethnomedizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik

Inhaltsverzeichnis

- Contents

- Foreword Eric D. Green, MD, PhD

- Preface Karen H. Rothenberg and Lynn W. Bush

- Chapter 1 SETTING THE GENOMIC STAGE:

- Why Genomics, Why Narratives, Why Now?

- Exploring Ethical, Psychosocial and Policy Challenges of Next-Gen Sequencing

- Part I Narrative Genomics: Exploring Process in Context

- Chapter 2 ANTICIPATING THE FUTURE:

- Genomic Protocols and Ethics Consultations

- Scene I The IRB Meeting

- Scene II The Genomic Advisory Committee

- Online Play "Imagining a Genomic Crystal Ball"

- Additional Questions

- Chapter 3 INFORMING THE FUTURE:

- The Process of Consent and Disclosure of Genomic Information

- Scene I The Informed Consent Process

- Scene II The Return of Genomic Findings

- Online Play "It's Not That Simple" and "It's So Complicated"

- Additional Questions

- Chapter 4 REFRAMING AN "OPEN FUTURE":

- The Shifting Landscape From NBS to NBSeq

- Scene I The Paradoxes of NBSeq

- Scene II The Practical Concerns in "Pandora's Box"

- Online Play "The Paradoxes in Pandora's Box"

- Additional Questions

- Part II Integrating Narrative Genomics: A Case Study Drama

- Chapter 5 RECONCEPTUALIZING THE PAST, PRESENT and FUTURE:

- Next Gen Sequencing - "What's Next?!"

- Scene I The IRB Deliberation

- Scene II The Informed Consent Process

- Scene III The Clinical Ethics Consultation

- Scene IV The Return of Genomic Findings

- Online Play "What's Next?!"

- Additional Questions

- Part III Narrative Genomics on Stage: DNA, Society and Theatre

- Chapter 6 DRAMATIZING THE PAST, PRESENT and FUTURE:

- Theatrical Narratives from Genetics to Genomics

- Section I The Theatrical Double Helix and "Chromozones"

- Section II Mapping and Manipulating Fate

- Section III A Genomic Crystal Ball in the Post-Mapping Decade

- Additional Questions

- REFERENCES

Über Autor(innen)

Lynn Bush, PhD, MS, MA is on the faculty of Pediatric Clinical Genetics at Columbia University Medical Center, a faculty associate at their Center for Bioethics, and serves as an ethicist on pediatric and genomic advisory committees for numerous academic medical centers and professional organizations. Dr. Bush has an interdisciplinary graduate background in clinical and developmental psychology, bioethics, genomics, public health, and neuroscience that informs her research, writing, and teaching on the ethical, psychological, and policy challenges of genomic medicine and clinical research with children, and prenatal-newborn screening and sequencing.

Karen H. Rothenberg, JD, MPA serves as Senior Advisor on Genomics and Society to the Director, National Human Genome Research Institute and Visiting Scholar, Department of Bioethics, Clinical Center, National Institutes of Health. She is the Marjorie Cook Professor of Law, Founding Director, Law & Health Care Program and former Dean at the University of Maryland Francis King Carey School of Law and Visiting Professor, Johns Hopkins Berman Institute of Bioethics. Professor Rothenberg has served as Chair of the Maryland Stem Cell Research Commission, President of the American Society of Law, Medicine and Ethics, and has been on many NIH expert committees, including the NIH Recombinant DNA Advisory Committee.