Buch, Englisch, Band 78, 398 Seiten, Format (B × H): 157 mm x 236 mm, Gewicht: 771 g
Reihe: Drug Discovery
Buch, Englisch, Band 78, 398 Seiten, Format (B × H): 157 mm x 236 mm, Gewicht: 771 g
Reihe: Drug Discovery
ISBN: 978-1-78801-187-7
Verlag: RSC Publishing
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Introduction; Protein-protein interaction interfaces and their functional implications; Protein-Protein interaction networks in human disease; High Throughput Screening Methods for PPI inhibitor discovery; Computational structural modeling to discover PPI modulators; Small molecule inhibitors of E3 ubiquitin ligases; Hydrogen bond surrogate stabilized helices as Protein-Protein interaction inhibitors; Helix-mimetics as Protein-Protein Interaction Inhibitors; Discovery and Development of Mcl-1 Inhibitors as Anti-cancer Therapeutics: Hit to Clinical Candidate Optimization; Pharmacological Regulation and Functional Significance of Chromatin Binding by BET Tandem Bromodomains; Small-molecule modulators of Protein-Protein Interactions: focus on 14-3-3 PPIs; Discovery of AMG 232, a small molecule MDM2 inhibitor in clinical development and its back-up clinical candidate, AM-7209; Small Molecule Inhibitors of Myc-Max Interaction and DNA Binding; Small Molecule Modulators of Endo-Lysosomal Toll-Like Receptors