Biofluids for the Modelling of Physiological Flows: I. Microflows at cellular scale

Erscheinungsjahr 2029
ISBN: 978-0-323-89969-7
Verlag: William Andrew Publishing

Buch, Englisch, Format (B × H): 216 mm x 276 mm

Biomechanics of physiological flows continues to be an emerging research field since the pioneer works conducted by the groups of Prof. Fung, McDonald and Caro on hemodynamics. It has been a very active field of research largely benefitting from the incommensurable improvements of imaging and visualization technologies both in the clinical and laboratory environments, exponential rise of numerical capabilities and the advent of experimental technologies among which one can cite microfluidics. All these have revolutionized research in Biofluids and on Cardiovascular Flows. The 2nd Volume of the Biomechanics of Living Organs series, entitled "Biofluids for Modelling of Physiological Flows: I. Microflows at cellular scale� will provide an overview of the biomechanical aspects of physiological flows, with an emphasis on microflows at cellular scale. It will provide students, researchers, clinicians and engineers with a comprehensive set of interdisciplinary knowledge on the main scientific topics and issues related to microflow modelling. This volume will not only include outstanding examples of modelling the cellular response to physiological microflow conditions in humans, thus improving the understanding of mechanotransduction processes, but also present original microfluidic devices and applications in biomicromechanics.

Autoren/Hrsg.

SALSAC, Anne-Virginie

Schmid-Sch�nbein, Geert W.

Fachgebiete

• Technische Wissenschaften Technik Allgemein Technik: Allgemeines

Inhaltsverzeichnis

Note of the Series Editors

Foreword

Preface

Section 1. Background 1.�Microhydrodynamics: governing equations of low-Reynolds-number flow (Oliver Jensen -Manchester University) - To be contacted 2.�Physiological complexity of the body microflows (arteriole/capillary flows - time variations, interstitial fluid flows, osmotic effects.) (Takami Yamaguchi, Takuji Ishikawa) - To be contacted 3.�Biological membranes: influence on trafficking and transport, health and disease (Helen Watson - University of Exeter) - To be contacted 4.�Intracellular processes (Brownian motion, stochastic effects, endocytosis, exocytosis) (Paul C. Bressloff - University of Utah, Jay M. Newby) - To be contacted 5.�Endothelial cell response to flow (by a biologist - EC receptors and signaling pathway, glycocalyx,.)� (1. Dennis Discher - Penn Eng. 2. Chris Chen - Boston Univ) - To be contacted 6.�Mechanobiology of smooth muscle cells (by a biologist) (Richard C.M. Siow - Kings College London) - To be contacted 7.�Mechanobiology of leukocytes (by a biologist) (Timmerman I, Daniel AE, Kroon J, van Buul JD - University of Amsterdam; Michael King - Vanderbilt) - To be contacted 8.�Mechanobiology of platelets (by a biologist) (Larry McIntire or one of his students; Lam Hansen - Georgia Tech) - To be contacted

Section 2. Modeling of cell response to physiological flows (Mechanobiology by biomechanicians)� 1.�Modeling of endothelial cell response to flow and pressure (+ influence of glycocalyx) (Shu Chien, John Shyy) - To be contacted 2.�Modeling of leucocytes in flow: shear stress response, rolling, diapedesis (1. Klaus Ley, 2. Michael Laurence - Univ Virginia, 3. Michael King, Cheng Dong) - To be contacted 3.�Modeling of platelet response leading to coagulation (David Ku - Georgia Tech, Cyrus Aidun) - To be contacted 4.�Modeling of intracellular motion and transport (Micah Dembo Boston = modeler, Cheng Zhu -Georgia Tech) - To be contacted 5.�Modeling of smooth muscle cell response (John Tarbell) - To be contacted

Section 3. Modeling of microflows 1.�Modeling of bioartificial capsules under flow - characterization of the membrane mechanical properties (Dominique Barth�s-Biesel, Anne-Virginie Salsac) - Confirmed 2.�Modeling of red blood cells in the microcirculation (Prosenjit Bagchi) - To be contacted 3.�Modeling of sperm cell locomotion (Takuji Ishikawa, Tim Pedley) - To be contacted 4.�Modeling of tumor angiogenesis (1. Aleksander S. Popel, John Hopkins Univ, 2. Somone from Harvard group bioengineering in the follow-up of Judah Folkman) - To be contacted 5.�Modeling of blood clots under arterial shear (Alexander Y. Mitrophanov, Henry M. Jackson Foundation for the Advancement of Military Medicine) - To be contacted 6.�Fungus dispersion in low-velocity airflow (Nicholas Money - Oxford University) - To be contacted

Section 4. Microfluidic devices and applications for microflow modeling 1.�Drug target optimization (Saami Yazdani - Univ South Alabama) - To be contacted 2.�Cell-to-cell interaction studies (Peter Ertl - Institute of Chemical Technologies and Analytics) - To be contacted 3.�Drug screening and toxicological testing (Fr�d�ric Bois - INERIS) - To be contacted 4.�Cell sorting (Roger Kamm - MIT) 5.�Cancer tumor cell invasion (Subra Surech - MIT) - To be contacted 6.�Microfluidic instruments to isolate cells (Anne Leyrat-Maurin - Instrumentation Fluidigm) - To be contacted 7.�Microfluidic devices to study embryo biomechanics (David Lai, Shuichi Takayama, Gary Smith - University of Michigan). - To be contacted

Über Autor(innen)

Schmid-Sch�nbein, Geert W.
Geert W. Schmid-Sch�nbein is Distinguished Professor in the Department of Bioengineering at the University of California San Diego (UCSD). He studied physics as undergraduate at the Justus Liebig University in Giessen, Germany, and received a Ph.D. degree in Bioengineering at UCSD. Following three years as Post-doctoral Fellow in the Department of Physiology of Columbia University, New York, he joined the faculty of the Department of Bioengineering at UCSD in 1979 where he served ever since. He uncovered the mechanotransduction response of white blood cells under fluid shear stress, and discovered the second valve system in lymphatics that is required for lymph fluid from the tissue. Later, he concluded that the survival of an acutely ill patient can hinge on the degree to which white blood cells are activated. His team studies a mechanism for disease and death due to digestive enzymes, which they referred to as "autodigestion". They designed new instrumentations to detect digestive enzymes, monitor their transport and activity, and develop new approaches to reduce their destructive actions. He is Past Chair of the US National Committee on Biomechanics and Past Chair of the World Council for Biomechanics. Among his many distinctions, he is a member of the National Academy of Engineering and a fellow of the American Heart Association. He is a founding fellow of the American Institute for Medical and Biological Engineering, and winner of the Melville Medal from the American Society of Mechanical Engineering, the Poiseuille Gold Medal by the International Society for Biorheology, and Eugene M. Landis Award by The Microcirculatory Society.

SALSAC, Anne-Virginie
Anne-Virginie Salsac is Director of Research at the CNRS, in the Biomechanics and Bioengineering Laboratory at the Universit� de Technologie de Compi�gne (France), and Visiting Professor at the Institute of Bioengineering, Queen Mary University of London (UK) since 2014. She joined the CNRS, after having graduated from University of California, San Diego (USA) in 2005 with a PhD in Biofluids, and being a Lecture in the Department of Mechanical Engineering of University College London (UK). She is specialized in biofluids applied to the study of hemodynamics from the large blood vessels to the microcirculation, and of biomedical engineering applications. She has a double expertise in in vitro and in silico modeling of blood flows. She studies, among others, the behavior of bioartificial and natural capsules in microchannels and develops new therapeutic and

preventive approaches through the use of microcapsules and of endovascular biomedical devices. Anne-Virginie Salsac was distinguished for her pluridisciplinary research studies with various prices and awards, including the CNRS Bronze Medal in 2015, 2 'Troph�es des Femmes en Or' in 2015 and the Medal of the National Order of Merit in 2016. She was awarded an ERC Consolidator grant in 2017 and is strongly involved in dissemination of scientific activities.