PeroxisOMICS

Identifying Novel Functions and Regulatory Networks of Peroxisomes
Erscheinungsjahr 2027
ISBN: 978-3-032-35651-2
Verlag: Springer

Buch, Englisch, 414 Seiten, Format (B × H): 155 mm x 235 mm

Reihe: Subcellular Biochemistry

This volume provides a comprehensive, state-of-the-art overview of “omics” approaches used to investigate peroxisomes of mammalian, fungal, and plant origin, and includes contributions from leading experts in the field. The development and application of omics approaches—including advanced proteomics and mass spectrometry technologies, metabolomics, and lipidomics—combined with bioinformatics methods now enable the identification of low-abundance and transient peroxisomal proteins and allow for the characterization of the complete peroxisomal proteome. They also facilitate the analysis of alterations in lipid composition and metabolic activities, thereby increasing our understanding of the metabolic and regulatory networks of these medically important cellular organelles.
This book aligns with these developments and aims to provide valuable insights for molecular cell biologists, biochemists, and biomedical researchers with an interest in peroxisome and organelle biology.

Zielgruppe

Research

Autoren/Hrsg.

Schrader, Michael

Islinger, Markus

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

Chapter 1: The mammalian peroxisomal proteome 2.0 – an update.- Chapter 2: The craft of peroxisome purification, a technical survey through the decades, 2nd revised and extended edition.- Chapter 3: New Perspectives on the Peroxisomal Proteome of Pepper (Capsicum annuum) Fruits: The Persulfidome.- Chapter 4: Compartmentalized Complexity: The spatial organization of the Proteome of Peroxisomes.- Chapter 5: Influence of genomic variability on the peroxisomal proteome.- Chapter 6: Interactome analysis of the affinity-purified peroxisomal membrane protein PEX13.- Chapter 7: The role of lipidomics in studying human peroxisome-mediated lipid homeostasis.- Chapter 8: Linking Organelle Structure to Function by Imaging.- Chapter 9: Multi-localized proteins at peroxisomes and mitochondria – an update.- Chapter 10: The role of peroxisomes in the heart: an omics-based view.- Chapter 11: Multi-omics revelation of how peroxisomes regulate immunometabolism and inflammation in organisms spanning invertebrates to humans.- Chapter 12: Key Players, Regulatory Mechanisms, and Therapeutic Potential.- Chapter 13: Unlocking the metabolic contribution of peroxisomes during human neurodevelopment.

Über Autor(innen)

Prof. Dr. Michael Schrader is Professor of Cell Biology & Cytopathology in the Dept. of Biosciences at the University of Exeter, UK. Using mammalian peroxisomes as model organelles, Prof. Schrader and his team aim to unravel the molecular machinery and signalling pathways that mediate and regulate the formation, dynamics, abundance and interplay of these medically relevant cellular compartments. Prof. Schrader is Editor-in-Chief (Greater Europe) for the Springer Journal "Histochemistry & Cell Biology" and has served as editor for several Springer books (DOI 10.1007/978-1-4939-6937-1; DOI 10.1007/978-981-13-2233-4;  DOI 10.1007/978-1-0716-3048-8) and/or contributed to those (e.g. DOI 10.1007/978-3-7091-1788-0; DOI 10.1007/978-1-62703-056-4; DOI 10.1007/978-94-007-6889-5) based on his long-standing expertise in peroxisome/organelle biology.

Dr. Markus Islinger is group leader in the Dept. of Neuroanatomy of the Medical Faculty Mannheim, Heidelberg University. His research interests in peroxisome biology focus on the characterization of peroxisomal functions and dynamics in neurons and glial cells to increase our understanding of their contribution to development and metabolic homeostasis of the brain as well as the retina in human health and disease. M. Islinger contributed to several Springer books based on his longstanding expertise in peroxisome biology and organellar proteomics (e.g. DOI 10.1007/978-1-59745-028-7; DOI 10.1007/978-1-61779-959-4; DOI 10.1007/978-1-61779-111-6; DOI 10.1007/978-1-62703-056-4; DOI: 10.1007/978-1-4939-6937-1; DOI: 10.1007/978-981-13-2233-4).