Navigating Tuberculosis

Insights Into Host-Pathogen Protein Interactions
Erscheinungsjahr 2026
ISBN: 978-0-443-27735-1
Verlag: Elsevier Science

Buch, Englisch, 325 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 449 g

Navigating Tuberculosis: Insights into Host-Pathogen Protein Interactions, the latest release in the Foundations and Frontiers in Enzymology series, explores the interactions between host proteins and the tuberculosis pathogen, Mycobacterium tuberculosis (M. tb), emphasizing their roles in virulence and pathogenesis. The book delves into mechanistic insights, focusing on their roles in modulating innate and adaptive immunity and understanding TB pathomechanisms by elucidating the interplay between host defenses and M. tb infection. It provides a foundation for developing targeted mitigation strategies and discusses key regulatory pathways and protein factors involved in host-pathogen interactions, informing the design and implementation of innovative approaches to combat TB.

This comprehensive volume aims to advance knowledge and strategies to combat tuberculosis, aligning with the World Health Organization's goal of eradicating TB by 2035 by addressing the need for up-to-date information on host-pathogen interactions in tuberculosis and incorporating the latest research findings and advancements. It highlights emerging therapeutic targets among host and TB pathogen proteins and integrates multidisciplinary approaches from microbiology, immunology, and molecular biology, offering a holistic perspective on TB pathophysiology. Researchers will find detailed discussions on key host proteins involved in tuberculosis pathogenesis, the molecular tactics employed by M. tb to subvert host defenses, and host-mediated inhibition strategies targeting M. tb.

Autoren/Hrsg.

Shariq, Mohammad

Hasnain, Seyed Ehtesham

Ehtesham, Nasreen Zafar

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Chemotherapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Infektionskrankheiten

Inhaltsverzeichnis

SECTION I: Mycobacterial virulence and host interaction
1. Mechanisms of Mycobacterium tuberculosis virulence: The ESX1 locus and host countermeasures
2. Mycobacterial PE/PPE proteins: Key regulators of apoptosis and pathogenic outcomes
3. Unraveling Mycobacterium tuberculosis pathogenesis: Insights into PE/PPE proteins from a molecular viewpoint
4. Host-pathogen dynamics in Mycobacterium tuberculosis: The impact of PE/PPE proteins on innate and adaptive immunity

SECTION II: Host defense mechanisms and cellular responses
5. Mechanisms of phagosomal damage detection and response to Mycobacterium tuberculosis: Repair, autophagy, and biogenesis
6. Autophagy and Mycobacterium tuberculosis: Host defense mechanisms versus pathogen evasion
7. Unraveling NCoR1’s role in Mycobacterium tuberculosis pathogenicity
8. Division: An eternal rhythm of the cells
9. Programmed cell death during Mycobacterium tuberculosis infection: The roles of pyroptosis and necroptosis in host defense
10. Unraveling the cellular battlefield: Mycobacterium tuberculosis and its interplay with host cell death pathways

SECTION III: Therapeutic frontiers and drug repurposing
11. Repurposing potential of cell wall-modulating drugs: A new frontier in TB management
12. Metabolic repurposing in Mycobacterium-infected macrophages: A strategy for enhanced virulence and survival
13. Revolutionizing TB therapy: Emerging opportunities and unresolved challenges

SECTION IV: Nutrition, immunity, and broader mycobacterial contexts
14. The enigma of food supplementation in TB: A role for unresolved inflammation
15. Immunological insights: How macrophages combat non-tuberculous mycobacteria
16. Extra-Pulmonary tuberculosis: Insights into mitigation and control
17. Multifaceted approaches to tuberculosis management: Bridging molecular discovery and public health impact

Über Autor(innen)

Hasnain, Seyed Ehtesham
Professor Seyed E. Hasnain is a distinguished figure in tuberculosis research, specializing in infection biology and functional epidemiology. His groundbreaking contributions have earned him international recognition and a multitude of prestigious awards, including the Robert Koch Fellowship in Berlin, Membership of the American Academy of Microbiology, and induction into the German National Academy of Sciences-Leopoldina. He is also a Fellow of TWAS (Italy) and all major Indian Science Academies (FNA/FASc/FNASc). Prof. Hasnain's accolades further include the Alexander von Humboldt Research Award, the Shanti Swarup Bhatnagar Prize, the GD Birla Award, and the JC Bose Fellowship. With a distinguished career spanning decades, Prof. Hasnain has served in various esteemed roles. Notably, he was a member of the Science Advisory Council to the Prime Minister of India for two terms (2004-2014), the inaugural Director of the Centre for DNA Fingerprinting and Diagnostics in Hyderabad, and subsequently the Vice-Chancellor of the University of Hyderabad from 2005 to 2011, and the Vice-Chancellor of Jamia Hamdard University (2016-2021). He also held the esteemed position of invited Prof. at IIT-Delhi from 2011 to 2019. Presently, Prof. Hasnain serves as a National Science Chair at the Indian Institute of Technology, Delhi (IIT-D), and is also a Distinguished Professor at Sharda University.

Shariq, Mohammad
Dr. Mohd Shariq, Ph.D., obtained his doctoral degree in Biological Sciences from Jawaharlal Nehru University, India, focusing on Cellular and Molecular Biology of Infectious Diseases. He has authored 30 peer-reviewed articles in prestigious journals like Autophagy, Journal of Medical Virology, European Respiratory Review, and Frontiers in Immunology. Dr. Shariq has mentored numerous students in independent research projects and is joining GITAM University, Hyderabad, as an Assistant Professor, bringing extensive expertise in Cellular and Molecular Biology and Microbiology. Previously, as a Senior Scientist and Group Leader at QuantLase Imaging Laboratory, he published four research articles in reputed international journals such as Cellular and Molecular Biology Letters (Springer). His research on host-pathogen interactions in tuberculosis and the role of M. tb proteins in inflammation and autophagy regulation has significantly advanced the understanding of TB pathomechanisms. Additionally, his insights into drug resistance mechanisms in Candida albicans and Helicobacter pylori infections have enriched our understanding of microbial pathogenesis. Dr. Shariq serves as an acting reviewer for esteemed journals like Frontiers, Scientific Reports, and others, and acts as a review editor for Gut Pathogens and Frontiers.

Ehtesham, Nasreen Zafar
Professor Nasreen Z. Ehtesham completed her Master's degree at Aligarh Muslim University, Aligarh, and pursued graduate training at the University of Alberta, Edmonton, Canada. She earned her Ph.D. from the National Institute of Immunology, New Delhi, in 1991, followed by a Rockefeller Postdoc Fellowship at the ICGEB. As Deputy Director at the National Institute of Nutrition, Hyderabad, her research group focused on nutrition and inflammation biology, particularly in elucidating the link between pathogenesis, inflammation, and stress response using the Mycobacterium tuberculosis infection model. Prof. Nasreen Ehtesham has contributed extensively to decision-making bodies of the Health Ministry and S&T Ministry and has published over 100 research papers in esteemed journals like PNAS, garnering over 5000 citations. She served as Director-in-Charge at the ICMR National Institute of Pathology, New Delhi, and is recognized as an Elected Fellow of the Indian National Science Academy, the National Academy of Sciences, India, and the Andhra Pradesh Akademi of Sciences, India. She has received numerous awards, including the ICMR Kshanika Award in 2014 and the Outstanding Work of the Year Award from NII, New Delhi, in 1990. Prof. Nasreen Ehtesham is a member of various professional societies and serves on the editorial boards of several esteemed journals, including Molecular and Cellular Biochemistry (Springer) and Gut Pathogens (BioMed Central). Presently, Prof. Nasreen Ehtesham is a Distinguished Professors at Sharda University.