Biofilm Eradication and Prevention

A Pharmaceutical Approach to Medical Device Infections
1. Auflage 2010
ISBN: 978-0-470-47996-4
Verlag: Wiley

Buch, Englisch, 438 Seiten, Format (B × H): 161 mm x 240 mm, Gewicht: 833 g

Biofilm Eradication and Preventions presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers need to take to limit this problem. Split into three parts, the first deals with the development and characterization of biofilm on the surfaces of implanted or inserted medical devices. Questions as to why biofilms form over medical device surfaces and what triggers biofilm formation are addressed. In the second section, the author discusses biofilm-mediated chronic infections occurred in various organs (eyes, mouth, wounds) and pharmaceutical and drug delivery knowledge gained from research in these area. The third part explores pharmaceutical approaches like lipid-and polymer-based drug delivery carriers for eradicating biofilm on device-related infections. In addition, this section also explores the topic of novel small molecule (like iron and its complexes/metal chelators) and a quorum-sensing inhibitors to control medical biofilm formation.

Autoren/Hrsg.

Shunmugaperumal, Tamilvanan

Fachgebiete

• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie Pharmaindustrie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

PREFACE.

ACKNOWLEDGMENTS.

PART I. DEVELOPMENT AND CHARACTERIZATION OF BIOFILMS.

1. INTRODUCTION AND OVERVIEW OF BIOFILM.

2. RATIONALE FOR BIOFILM ERADICATION FROM MODERN MEDICAL DEVICES.

3. PATHOGENESIS OF DEVICE-RELATED NOSOCOMIAL INFECTIONS.

4. BIOFILM RESISTANCE-TOLERANCE TO CONVENTIONAL ANTIMICROBIAL AGENTS.

5. ANALYTICAL TECHNIQUES USEFUL TO STUDY BIOFILMS.

PART II. BIOFILM-RELATED INFECTIONS IN VARIOUS HUMAN ORGANS (NONDEVICE-RELATED CHRONIC INFECTIONS).

6. BIOFILM-RELATED INFECTIONS IN OPHTHALMOLOGY.

7. BIOFILM-RELATED INFECTIONS IN THE ORAL CAVITY.

8. IMPLICATIONS OF BIOFILM FORMATION IN CHRONIC WOUNDS AND IN CYSTIC FIBROSIS.

PART III. DRUG DELIVERY CARRIERS TO ERADICATE BIOFILM FORMATION ON MEDICAL DEVICES.

9. STRATEGIES FOR PREVENTION OF DEVICE-RELATED NOSOCOMIAL INFECTIONS.

10. LIPOSOMES AS DRUG DELIVERY CARRIERS TO BIOFILMS.

11. POLYMER-BASED ANTIMICROBIAL DELIVERY CARRIERS.

INDEX.

Über Autor(innen)

TAMILVANAN SHUNMUGAPERUMAL, PhD, works in the Department of Pharmaceutical Technology at the International Medical University in Kuala Lumpur, Malaysia. His current research seeks to exploit the potential of lipid- and polymer-based drug delivery carriers to eradicate infectious biofilm formation associated with both medical devices and human organs.