Endothelial Cell Biology in Health and Disease

Erscheinungsjahr 2011
ISBN: 978-1-4612-8254-9
Verlag: Springer

Buch, Englisch, 478 Seiten, Format (B × H): 170 mm x 244 mm, Gewicht: 828 g

Although blood capillaries were first observed through a flea-lens microscope by Malpighi in 1661,200 more years elapsed before the cellular nature of the vessel wall was conclusively demonstrated. Beginning with the middle of the 19th cen tury, our knowledge of the histological organization of blood vessels has steadily increased. However, the endothelium, which for a long time was considered to be just an inert barrier lining, had been barely explored until three decades ago. Since then, there has been an upsurge of interest in the fine structure and function of endothelial cells. Intense in vivo and in vitro investigations have revealed that the endothelial cell is a key element in a wide variety of normal activities and diseases. A large number of investigators and laboratories have been attracted to endothelial cell research, thus supporting the expansion of the continuously grow ing and diversifying field of endotheliology. The number of articles published annually on this subject has increased from a few score at the beginning of the 1970s to more than a thousand in recent years, and an increasing number of journals, books, societies, and symposia focused primarily on the vascular en dothelium have marked the last decade.

Zielgruppe

Research

Autoren/Hrsg.

Simionescu, M.

Inhaltsverzeichnis

I. Structure-Function Correlations in Endothelial Cells.- 1. The Microvascular Endothelium Revisited.- 2. Ultrastructural Studies of Capillary Endothelium: Compartmental Tracing, High-Voltage Electron Microscopy, afid Cryofixation.- II. Transport Functions of Endothelial Cells.- 3. Transport Pathways and Processes.- 4. Receptor-Mediated Trariscytosis of Plasma Molecules by Vascular Endothelium.- 5. Studies of Pulmonary Endothelial Permeability Using Tritiated Dextrans.- III. Endothelial Cell Growth and Differentiation.- 6. Endothelial Morphogenesis.- IV. Endothelial Cytoskeleton and Matrix and Their Interactions.- 7. The Endothelial Junction: The Plaque and Its Components.- 8. Endothelial Cell-Extracellular Matrix Interactions: Matrix as a Modulator of Cell Function.- V. Endothelial Cell Anticoagulant and Fibrinolytic Activities.- 9. Assembly and Function of the Protein C Anticoagulant Pathway on Endothelium.- 10. The Biochemistry and Physiology of Anticoagulantly Active Heparinlike Molecules.- 11. The Fibrinolytic System of Cultured Endothelial Cells.- VI. Endothelial Cell Procoagulant Activity.- 12. Vascular Endothelium: Functional Modulation at the Blood Interface.- 13. Endothelium and the Regulation of Coagulation.- VII. Endothelial Cell Response to Stress Factors.- 14. Heat-Shock Response as a Possible Model for (Patho)physiological Stress in Endothelial Cells.- 15. Endothelial Activation: Its Role in Inflammatory and Immune Reactions.- 16. Intimal Responses to Shear Stress, Hypercholesterolemia, and Hypertension: Studies in the Rat Aorta.- VIII. Endothelial Cell in Atherogenesis.- 17. Endothelial Injury and Atherosclerosis.- 18. Prelesional Changes of Arterial Endothelium in Hyperlipoproteinemic Atherogenesis.- 19. Response of Blood Vessel Cells to Viral Infection.