Mitochondria and Cancer

1. Auflage. Softcover version of original hardcover Auflage 2009
ISBN: 978-1-4419-2738-5
Verlag: Springer

Buch, Englisch, 289 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 464 g

Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book,  , edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.

Zielgruppe

Research

Autoren/Hrsg.

Singh, Keshav

Costello, Leslie

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung

Inhaltsverzeichnis

Mitochondria and Cancer.- Warburg and his Legacy.- The Lipogenic Switch in Cancer.- Citrate Metabolism in Prostate and Other Cancers.- Integration of Genetic, Proteomic, and Metabolic Approaches in Tumor Cell Metabolism.- Mitochondrial Respiration and Differentiation.- Integration of Energy Metabolism and Control of Apoptosis in Tumor Cells.- Energy Generating Pathways and the Tumor Suppressor p53.- Mitochondrial Tumor Suppressors.- Mitochondria in Hematology.- Mitochondria and Oncocytomas.- Mitochondria as Targets for Cancer Therapy.- Reversing the Warburg Effect: Metabolic Modulation as a Novel Cancer Therapy.- Mitochondrial Nanotechnology for Cancer Therapy.