Bioinformatics

Methods and Applications
Erscheinungsjahr 2021
ISBN: 978-0-323-89775-4
Verlag: Elsevier Science

Buch, Englisch, 510 Seiten, Format (B × H): 216 mm x 274 mm, Gewicht: 1361 g

Bioinformatics: Methods and Applications provides a thorough and detailed description of principles, methods, and applications of bioinformatics in different areas of life sciences. It presents a compendium of many important topics of current advanced research and basic principles/approaches easily applicable to diverse research settings. The content encompasses topics such as biological databases, sequence analysis, genome assembly, RNA sequence data analysis, drug design, and structural and functional analysis of proteins. In addition, it discusses computational approaches for vaccine design, systems biology and big data analysis, and machine learning in bioinformatics.It is a valuable source for bioinformaticians, computer biologists, and members of biomedical field who needs to learn bioinformatics approaches to apply to their research and lab activities.

Autoren/Hrsg.

Singh, Dev Bukhsh

Pathak, Rajesh Kumar

Fachgebiete

• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie Spitzentechnologiesektor
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizinische Mathematik & Informatik
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik

Inhaltsverzeichnis

1. Introduction to Basics of Bioinformatics 2. Biological Databases and their Applications 3. Biological Sequence Analysis 4. Genome Assembly and Annotation 5. Computational Molecular Phylogeny: Concepts and Applications 6. Applications and challenges of microarray and RNA-sequencing 7. RNAseq Data Analysis 8. Analysis of SSR and SNP Markers 9. Gene Ontology (GO): Application and Importance in Functional Annotation of the Genomic Data 10. Metagenomics: The Boon for Microbial World Knowledge and Current Challenges 11. Protein structure Prediction 12. Structural and Functional analysis of protein 13. Computational Approaches in Drug designing 14. Structure-Based Drug Designing 15. Ligand-Based Drug Designing 16. Discovery and Optimization of Lead Molecules in Drug Designing 17. Pharmacophore modeling and its applications 18. Molecular Docking and Molecular Dynamics Simulation 19. Pharmacokinetics and Pharmacodynamics analysis of Drug Candidates 20. Computational Approaches for Vaccine Designing 21. Metabolomics and Flux Balance Analysis 22. Topological Parameters, Patterns, and Motifs in Biological Networks 23. Network Biology and its Application 24. Pathway Modeling and Simulation Analysis 25. Systems Biology and Big Data Analytics 26. Machine Leaning in Bioinformatics 27. Bioinformatics and Biological Data mining

Über Autor(innen)

Singh, Dev Bukhsh
Dr. Dev Bukhsh Singh is Assistant Professor in the Department of Biotechnology at Siddharth University, Kapilvastu, India, a position he has held since 2021. Previously, he served as Assistant Professor in the Department of Biotechnology at Chhatrapati Shahu Ji Maharaj University, Kanpur, India, from 2009 to 2021. His research focuses on medicinal biology, lead compound discovery, and drug design. He has been involved in teaching and mentoring undergraduate and postgraduate students in biotechnology since 2009. Dr. Singh has edited books in the areas of protein structure and function, computer-aided drug design, Protein-based therapeutics, medicinal biotechnology, genomics, and bioinformatics. He is a member of professional academic organizations and serves as a reviewer for scholarly journals. His academic interests include applying computational and biotechnological approaches to drug discovery and related life science research.

Pathak, Rajesh Kumar
Rajesh Kumar Pathak completed his BSc from Barkatullah University, Bhopal, MSc from Chhatrapati Shahu Ji Maharaj University, Kanpur, and PhD from Uttarakhand Technical University, Dehradun, India. He has authored several articles in international journals including, Scientific Reports, Computational Biology and Chemistry, OMICS: A Journal of Integrative Biology, Frontiers in Plant Science, 3 Biotech, Journal of Biomolecular Structure and Dynamics, etc. His research interests lie in the areas of the genome and transcriptome assembly and annotation, microarray data analysis, pathway modeling, and network analysis, molecular docking, virtual screening, and molecular dynamics simulation. He has worked as a Teaching Personnel at G. B. Pant University of Agriculture & Technology, Pantnagar, India, and Teaching Assistant at the School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana, India.