Electrocardiography of Laboratory Animals

3rd Auflage
ISBN: 978-0-443-33252-4
Verlag: Elsevier Science

Buch, Englisch, 200 Seiten, Format (B × H): 216 mm x 276 mm, Gewicht: 449 g

Electrocardiography of Laboratory Animals, Third Edition, is an essential resource for biological and medical researchers, veterinarians, zoologists, and students. With the increasing global emphasis on the ethical care and use of laboratory animals in research, this comprehensive guide provides a standardized approach to performing and analyzing electrocardiograms (ECGs) across all species used in today’s research. The book provides the latest information on critical topics such as safety electrocardiography, toxicology, safety pharmacology, and telemetry, ensuring that readers are well-equipped with the knowledge required for accurate ECG interpretation in preclinical studies. The book is carefully organized into detailed chapters, beginning with the fundamental principles of electrocardiography and its application in drug safety evaluation. It covers the electrocardiography of a wide range of laboratory animals, including rodents, guinea pigs, rabbits, cats, dogs, and various non-human primates such as marmosets, cynomolgus monkeys, rhesus monkeys, baboons, and chimpanzees. Additionally, it reviews the ECG characteristics of minipigs, nanopigs, and micropigs. The text also includes chapters on telemetry and echocardiography in preclinical safety studies, as well as discussions on important parameters like PR (PQ), QRS, and QT intervals. The book concludes with chapters on cardiac assays, biomarkers, stem cells, and cardiovascular medical devices, providing a holistic view of cardiovascular research. This enhanced and expanded Electrocardiography of Laboratory Animals, Third Edition offers invaluable insights and practical guidance, making it an indispensable tool for those involved in the care and study of laboratory animals. Its comprehensive coverage and detailed explanations ensure that readers can confidently conduct and interpret ECGs, thereby advancing the field of preclinical safety evaluation and contributing to the ethical and effective use of animals in research.

Autoren/Hrsg.

Sleeper, Meg M.

Richig, Jeffrey W.

Fachgebiete

• Medizin | Veterinärmedizin Veterinärmedizin Veterinärmedizin: Labortiere, Tierversuche
• Medizin | Veterinärmedizin Veterinärmedizin Veterinärmedizin: Innere Medizin, Gynäkologie & Reproduktion

Inhaltsverzeichnis

1. Electrocardiography in Preclinical Safety
2. Fundamental Principles of Electrocardiography
3. Electrocardiography of Rodents
4. Electrocardiography of Guinea Pigs
5. Electrocardiography of Rabbits
6. Electrocardiography of Cats
7. Electrocardiography of Dogs
8. Handling and Restraint of Non-Human Primates
9. Electrocardiography of Marmosets
10. Electrocardiography of Cynomolgus Monkeys
11. Electrocardiography of Rhesus Monkeys
12. Electrocardiography of Baboons
13. Electrocardiography of Chimpanzees
14. Electrocardiography of Minipigs
15. Electrocardiography of Nanopigs
16. Electrocardiography of Micropigs
17. Telemetry in Preclinical Safety Studies
18. Echocardiography in Preclinical Safety Studies
19. Pr (Pq), Qrs, Qt and Other Issues
20. Blood Pressure
21. Cardiac Assays, Cardiac Biomarkers and Cardiac Stem Cells
22. Cardiovascular Medical Devices
23. Self-Assessment

Über Autor(innen)

Richig, Jeffrey W.
Jeffrey W. Richig, DVM is CEO of ECGVET, LLC and Special Government Employee consultant to the FDA for the cardiovascular and renal drugs division. He has over twenty-five years of experience in electrocardiography for pre-clinical safety evaluation studies and is known as a leading expert in the field.

Sleeper, Meg M.
Meg Sleeper, VMD, graduated cum laude from the University of Pennsylvania veterinary school in 1993. She is an associate professor of cardiology and served as section chief from 2001 to 2011. Dr. Sleeper has published over 70 peer-reviewed original papers, more than 50 review papers or case reports, and authored 4 books. She has lectured at numerous prestigious conferences, including the American Heart Association and the American College of Veterinary Internal Medicine Forum, and has coordinated the small animal cardiology section at the AVMA conference since 2009. Dr. Sleeper has trained 18 veterinary cardiologists and joined the University of Florida veterinary school faculty in 2015. She serves on the editorial or review boards of 11 journals and has contributed to the Great Ape Heart Project since 2011, focusing on improving cardiac health in ape species.