Dysbiosis of the Evolved Intestinal Microbiome

Lessons for Health in Future Generations
1. Auflage 2025
ISBN: 978-3-7258-1524-1
Verlag: MDPI AG

Buch, Englisch, 150 Seiten, Format (B × H): 175 mm x 250 mm, Gewicht: 575 g

While it is clearly recognised that many non-communicable disorders are related to a disturbed microbiome (commonly called dysbiosis, a shortened term for microbiome failure: dysmicrobiosis), there is an absence of widely accepted underlying theories. The aim of this book is to show that all such disorders, be they weight gain, immune system disturbance, or poor mental health, stem from a single underlying problem: the failure to transfer key intestinal microbes from the mother to the new-born during birth. Furthermore, in contrast to the normal, exclusively bacterial approach, the book describes what might be called a “second generation” approach to the microbiome, that emphasises beneficial microeukaryotes acting to coordinate diverse bacterial functionality. Most importantly, lessons have been drawn to guide future research, the aim being to reintroduce these key microbes at the time of birth, alongside breast milk (bank milk if necessary) and before the immune system of the infant is fully established. If all goes as expected, not only can the present “triple plagues” of non-communicable disease be ameliorated more efficiently, but it should also be possible to banish such disease from future populations. Unfortunately, however, beneficial microeukaryotes will be hard to detect, while resistance-inducing oral antibiotics must be limited.

Zielgruppe

Professionals/Scholars

Autoren/Hrsg.

Smith, David

Über Autor(innen)

Smith, David
David Smith received his PhD from Salford University, UK, in 1980, with a thesis entitled “Ionophoric Benzimidazolones” covering the field of synthetic organic chemistry. He then carried out two years of postdoctoral work at Imperial College, London, UK, working with Professor Charles Rees, FRS, and becoming a Member of the Royal Society of Chemistry and a Chartered Chemist (MRSC, CChem) as well as gaining the qualification of Diploma of Imperial College (DIC). The bulk of his working life from 1984 onwards was spent in the pharmaceutical industry, including the Sanofi group of companies in Alnwick, Northumberland, UK, until retirement in 2013 at age 60.

Following retirement, Dr. Smith continued to seek opportunities to remain valuable to society at large, and it was at this stage that the concept of the intestinal microbiome was beginning to be taken seriously. By 2015, Dr. Smith had developed a novel view on microbiome-related non-communicable disease, and his opportunities for collaboration were markedly increased upon joining NoRCEL, the Network of Researchers on the Chemical Emergence of Life. Alongside members of NoRCEL, across the period 2019 to 2023, Dr. Smith was able to coordinate a series of nine increasingly well-regarded articles, in turn culminating in the production of this book.
Following retirement, Dr Smith continued to seek opportunities to remain valuable to society at large, and it was at this stage that the concept of the intestinal microbiome was beginning to be taken seriously. By 2015, Dr Smith had developed a novel view on microbiome-related non-communicable disease, and his opportunities for collaboration were markedly increased upon joining NoRCEL, the Network of Researchers on the Chemical Emergence of Life. Alongside members of NoRCEL, across the period 2019 to 2023, Dr Smith was able to coordinate a series of nine increasingly well-regarded articles, in turn culminating in the production of this book.