Gene Environment Interactions: Nature and Nurture in the Twenty-First Century

Erscheinungsjahr 2020
ISBN: 978-0-12-819613-7
Verlag: ACADEMIC PR INC

Buch, Englisch, 438 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 790 g

Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome’s intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders.

Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population.

Zielgruppe

<p>Human geneticists; human genomicists; translational researchers in medical genetics, genomic medicine, epigenetics, neuroscience, toxicology, public health, and environmental science; life science researchers; developmental biologists; pharmacologists in industry and academia</p>

Autoren/Hrsg.

Smith, Moyra

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen

Inhaltsverzeichnis

1. Interacting with the environment receiving and interpreting signals2. Environment as Provider3. Human Evolution and adaptations to environments and to pathogen encounters4. Genetic mechanisms in environmental adaptations 5. Epigenetics and the regulatory genome6. The microbiome: The external life forms within7. Human development, behaviors, impacts of environment and genetic variations8. Joint Roles of Genes and Environment in etiology of specific diseases9. Personalized Precision Medicine10. Identifying and mitigating effects of Harmful factors in the Intrinsic or Extrinsic Environment11. Questions relating to climate change

Über Autor(innen)

Smith, Moyra
Dr. Moyra Smith is a Professor Emerita in the Department of Pediatrics and Human Genetics, College of Health Sciences, at the University of California, Irvine, and in past years has held appointments at the National Institutes of Health and Johns Hopkins University. In 2017, the UCI Emeriti Association awarded Dr. Smith the UCI Outstanding Emerita Award in recognition of her continuing research on genetics and genomics, strong record of publications, active engagement with programs in the Department of Pediatrics, mentoring of graduate students, and involvement with the CART Autism Center at UCI. Dr. Moyra Smith has published more than 100 scientific articles in peer-reviewed journals such as Frontiers in Molecular Biosciences, Molecular Psychiatry, the Journal of Medical Genetics (JMG), and Cytogenetics Cell Genetics.