Seeking Cures

Design of Therapies for Genetically Determined Diseases
Erscheinungsjahr 2013
ISBN: 978-0-19-991586-6
Verlag: OUP US

Buch, Englisch, 320 Seiten, Format (B × H): 161 mm x 240 mm, Gewicht: 634 g

Progress in molecular and cellular biology has greatly enhanced our ability to accurately diagnose diseases that are caused by gene mutations, changes in genome structures, and altered gene expression; increased emphasis is now placed on translational research the clinical treatment of these genetically determined diseases.

Seeking Cures outlines the progress and implications of science's quest to identify therapeutic targets and initiate novel treatments at the gene, RNA, protein, and physiological levels. Also considered are aspects of treatment at the cellular level (e.g., those with hematopoietic stem cells or induced pluripotent stem cells).

Topics covered in this text include:

· outline of the processes typical for identifying disease-modifying therapies
· examples of newer therapeutic approaches in use or under investigation to treat lysosomal storage diseases, inborn errors of metabolism, mitochondrial functional defects, and specific monogenic diseases
· therapeutic designs for specific complex common diseases, including Alzheimer's disease, cancer, and autism

Through these specific examples, Seeking Cures provides a glimpse at the pursuit-and future-of personalized medicine.

Zielgruppe

Researchers and students in molecular and clinical genetics, biochemistry, biology, pharmacology and pharmaceutical sciences

Autoren/Hrsg.

Smith, Moyra

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Naturwissenschaften Biowissenschaften Molekularbiologie

Über Autor(innen)

Moyra Smith, MD, PhD, MFA, has been conductiong research in human genetics since 1965. For 19 years she served as Clinical Geneticist and Director of the Newborn Screening Program at the University of California, Irvine, where she now serves as Professor Emeritus. Her latest research includes studies of nuclear and mitochondiral genomics in autism.