Handbook of Basal Ganglia Structure and Function

2. Auflage 2016
ISBN: 978-0-12-802206-1
Verlag: Elsevier Inc

Buch, Englisch, 1036 Seiten, Format (B × H): 222 mm x 282 mm, Gewicht: 2970 g

Handbook of Basal Ganglia Structure and Function, Second Edition, offers an integrated overview of the structural and functional aspects of the basal ganglia, highlighting clinical relevance. The basal ganglia, a group of forebrain nuclei interconnected with the cerebral cortex, thalamus, and brainstem, are involved in numerous brain functions, such as motor control and learning, sensorimotor integration, reward, and cognition.

These nuclei are essential for normal brain function and behavior, and their importance is further emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson’s disease, Tourette’s syndrome, Huntington’s disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction.

This updated edition has been thoroughly revised to provide the most up-to-date account of this critical brain structure. Edited and authored by internationally acclaimed basal ganglia researchers, the new edition contains ten entirely new chapters that offer expanded coverage of anatomy and physiology, detailed accounts of recent advances in cellular/molecular mechanisms and cellular/physiological mechanisms, and critical, deeper insights into the behavioral and clinical aspects of basal ganglia function and dysfunction.

Zielgruppe

<p>Neuroscience researchers in need of an overview of recent advances regarding the basal ganglia, neuroscience clinicians seeking information on the pathophysiology and associated diseases, and neuroscience graduate students looking for basic information on structure and function</p>

Autoren/Hrsg.

Steiner, Heinz

Tseng, Kuei Y.

Fachgebiete

• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

Part A: The Basal Ganglia System and its Evolution
1. History of the Basal Ganglia
2. Anatomical Organization of the Basal Ganglia

3. Evolution of the Vertebrate Basal Ganglia

4. Cell Types in the Basal Ganglia

Part B: Anatomy and Physiology of the Striatum
5. Striatal Medium Spiny Projection Neurons and their Connections
6. Cholinergic Interneurons of the Striatum
7. GABAergic Interneurons of the Striatum

8. Dopamine Signaling in Striatal Medium Spiny Neurons
9. Endocannabinoid Signaling in the Striatum

10. Nitric Oxide Signaling in the Striatum

11. Adenosine Signaling in the Basal Ganglia

Part C: Anatomy and Physiology of Globus Pallidus, Subthalamic Nucleus and Substantia Nigra
12. The Globus Pallidus

13. The Subthalamic Nucleus
14. The Substantia Nigra Pars Reticulata
15. Subtypes of Midbrain Dopamine Neurons
16. Neurophysiology of Substantia Nigra Dopamine Neurons
17. Plasticity in Dopamine Neurons
18. Regulation of Extracellular Dopamine: Release and Reuptake

Part D: Network Integration
19. Organization of Corticostriatal Projection Neuron Types

20. Organization of Prefrontal-Striatal Connections

21. Gating of Cortical Input to the Striatum

22. Corticostriatal Synaptic Plasticity in Physiological and Pathological Conditions

23. Organization of the Thalamostriatal Systems

24. The Rostromedial Tegmental Nucleus: Connections to the Basal Ganglia
25. The Rostromedial Tegmental Nucleus: A Modulator of Dopamine Systems
26. Integrative Networks Across Basal Ganglia Circuits

Part E: Molecular Signaling in the Basal Ganglia
27. Second-Messenger Cascades

28. DARPP32/Phosphatase Signaling
29. Transsynaptic Regulation of Basal Ganglia Gene Expression
30. Psychostimulant-Induced Gene Regulation in Corticostriatal Circuits

31. Epigenetics in Neuropathologies of the Basal Ganglia

Part F: Basal Ganglia Function and Dysfunction
32. Investigating Basal Ganglia Function with Cell-Type-Specific Manipulations
33. Basal Ganglia Re-Entrant Loops: Roles in Action Selection and Reinforcement
34. Memory Systems in the Basal Ganglia
35. Basal Ganglia Dynamics During Action Sequence (Motor) Learning
36. Abnormal Activities in Cortico-Basal Ganglia Circuits in Movement Disorders
37. Morphological Plasticity in the Striatum Associated with Dopamine Dysfunction
38. Neuroinflammation in Movement Disorders
39. Basal Ganglia Disorders Related to Striosome/Matrix Compartments
40. Drug Addiction: the Neural and Psychological Basis of a Compulsive Incentive Habit
41. Parkinson’s Disease: Cross-Talk Between Environmental Factors and Gene Defects

42. Parkinson’s Disease: Molecular Determinants of Vulnerability in Dopamine Neurons
43. Parkinson’s Disease: Genetics

44. Molecular Mechanisms of L-DOPA-Induced Dyskinesia

45. Cell Therapy in Parkinson’s Disease: An Update
46. Huntington’s Disease: Molecular Basis

47. Huntington’s Disease: Insights from Animal Models
48. Dystonia
49. Tourette Syndrome
50. Deep-Brain Stimulation for Neurologic and Psychiatric Disorders

Über Autor(innen)

Steiner, Heinz
Heinz Steiner is Professor and Chair of the Department of Cellular and Molecular Pharmacology at the Chicago Medical School/Rosalind Franklin University of Medicine and Science in Chicago, Illinois. Dr. Steiner is an expert on the functional organization of the basal ganglia and related brain systems. His research focuses, in particular, on the role of the neurotransmitter dopamine in the regulation of basal ganglia–cortical interactions; his recent investigations examine how chronic enhancement of dopamine actions produce changes in gene regulation, and how these molecular alterations affect basal ganglia function and behavior. He has been the North America Regional Editor for the journal Basal Ganglia since 2011.

Tseng, Kuei Y.
Kuei Y. Tseng is Associate Professor in the Department of Cellular and Molecular Pharmacology at the Chicago Medical School/Rosalind Franklin University of Medicine and Science in Chicago, Illinois. Dr. Tseng’s research focuses on the neural bases of Parkinson’s disease, particularly the effects of dopamine loss within the cortico–basal ganglia circuitry and the mechanisms underlying information processing in the brains of individuals affected by Parkinson’s disease. He is the editor of two books on the cortex.