Vaccines for the Prevention of Cervical Cancer

Erscheinungsjahr 2009
ISBN: 978-0-19-958863-3
Verlag: Oxford University Press

Buch, Englisch, 176 Seiten, Print PDF, Format (B × H): 100 mm x 180 mm, Gewicht: 149 g

Cervical cancer is the second most common form of cancer found in women and is responsible for more than a quarter of a million deaths worldwide each year. With approximately 70% of cervical cancers now known to be caused by two oncogenic types of the human papillomavirus (HPV), there is great interest surrounding the approval of the vaccine for clinical use. Despite this, many questions remain about how the new vaccines should be implemented and how cervical cancer screening will change following vaccination.

This practical pocketbook provides an overview of the role of HPV in the pathophysiology of cervical cancer and its current screening and management, the principles of immune control of HPV infection in cervical cancer, and the challenges of implementing HPV vaccines and future developments. This revised edition includes updated trial data in the chapter on prophylactic HPV vaccination: current status.

Autoren/Hrsg.

Stern, Peter

Kitchener, Henry

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizinische Mathematik & Informatik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Epidemiologie, Medizinische Statistik

Inhaltsverzeichnis

- 1: Karin Denton: The UK cervical screening programme

- 2: Julia E. Palmer and John A Tidy: Management of cervical intraepithelial neoplasia (CIN)

- 3: Sally Roberts and Lawrence S. Young: Role of HPV in cervical carcinogenesis

- 4: F. Xavier Bosch, Silvia de Sanjosé, and Xavier Castallsagué: HPV and genital cancer: the essential epidemiology

- 5: Margaret E. Cruickshank: The role of HPV testing in cervical screening

- 6: Peter L. Stern: Natural immune control of HPV infection

- 7: Margaret A. Stanley: Prophylactic HPV vaccines: pre-clinical and proof of principle studies

- 8: Henry C. Kitchener: Prophylactic HPV vaccination: current status

- 9: Loretta Brabin: Introduction of HPV prophylactic vaccination

- 10: Rengaswamy Sankaranarayanan and Catherine Sauvaget: HPV vaccination in the developing world

- 11: Patrick Walker, Adeola Atilade, and Henry C. Kitchener: Screening post vaccination

- 12: Richard BS Roden: Second-generation HPV prophylactic vaccines

- 13: Sjoerd H. van der Burg: Therapeutic HPV vaccines

- 14: Peter L. Stern and Henry C. Kitchener: Conclusion

Über Autor(innen)

Peter L. Stern is Professor of Immunology, Patterson Institute of Cancer Research, Christie Hospital NHS Trust, University of Manchester, Manchester, UK

Henry C. Kitchener is Professor of Gynacological Oncology at St. Mary's Hospital, University of Manchester, manchester, UK