The Bipolar Brain

Integrating Neuroimaging and Genetics
2. Auflage 2022
ISBN: 978-0-19-757452-2
Verlag: Oxford University Press

Buch, Englisch, 328 Seiten, Format (B × H): 224 mm x 292 mm, Gewicht: 1134 g

Bipolar disorder is one of the most common, and disabling, conditions affecting humankind. Each year, millions of individuals struggle with the effects of this illness. Although clinically well recognized for decades, if not centuries, the causes of this condition remain incompletely understood. However, significant technological advances in both neuroimaging and genetic research have revealed clues about the neurophysiological basis of bipolar illness. In this second edition of The Bipolar Brain, leading experts in neuroimaging and genetics discuss recent discoveries in bipolar disorder that identify the structural, functional and chemical brain changes that seem to underlie this condition, as well as the possible genetic causes of these brain events. New technologies such as miRNA, cerebral blood flow, and fMRI are presented. Based upon these discussions, the authors then integrate these diverse considerations to develop a specific neurophysiological model of bipolar disorder. This model provides a resource to guide clinicians as they struggle to understand this illness, as well as a guide for future investigations into the causes of bipolar disorder. With this guide in hand, this book will lead to a new framework for understanding bipolar disorder in order to, ultimately, develop improved therapies for affected individuals and novel strategies to prevent the onset in children at risk for this condition.

Autoren/Hrsg.

Strakowski, Stephen

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Psychiatrie, Sozialpsychiatrie, Suchttherapie

Inhaltsverzeichnis

- Preface

- Contributors

- Chapter 1: Brain Imaging Techniques and their Application to Bipolar Disorder, Caleb M. Adler

- Chapter 2: Structural Brain Abnormalities in Bipolar Disorder, Marcella Bellani, Niccolò Zovetti, Marsal Sanches, Koji Matsuo, Jair C. Soares, and Paolo Brambilla

- Chapter 3: Functional Brain Imaging in Bipolar Disorder: Activation Studies, Dylan E. Kirsch, Valeria Tretyak, Stephen M. Strakowski, and Elizabeth T.C. Lippard

- Chapter 4: Functional Brain Imaging in Bipolar Disorder: Connectivity And Networks, Jennifer E. Siegel- Ramsay and Jorge R.C. Almeida

- Chapter 5: Neurochemical and Metabolic Imaging in Bipolar Disorder, Muharrem Burak Baytunca, In Kyoon Lyoo, and Perry F. Renshaw

- Chapter 6: Cerebral Blood Flow in Bipolar Disorder: Past Findings and Future Directions, Megan Mio, Mikaela K. Dimick, Simina Toma, Bradley J. MacIntosh, and Benjamin I. Goldstein

- Chapter 7: Neuroimaging Studies of Bipolar Disorder in Youth, Manpreet K. Singh and Melissa P. DelBello

- Chapter 8: Neuroimaging Differences Between Bipolar and Unipolar Depression, Michele A. Bertocci, Jennifer E. Siegel- Ramsay, Jorge R.C. Almeida, Stephen M. Strakowski, and Mary L. Phillips

- Chapter 9: Neuroimaging in Bipolar Disorder and Schizophrenia, Grace Du and Dost Öngür

- Chapter 10: Genetic Techniques and Applications to Bipolar Disorder, Yuhua Zhang, Melvin G. McInnis, and Sebastian Zöllner

- Chapter 11: General Genetics of Bipolar Disorder, John I. Nurnberger Jr.

- Chapter 12: MiRNAs as Predictors of Bipolar Disorder Diagnosis and Treatment Response, Yogesh Dwivedi

- Chapter 13: Genetics of Bipolar Disorder and Schizophrenia, Tim B. Bigdeli and Philip D. Harvey

- Chapter 14: Mitochondrial Genetics and Bipolar Disorder, Christine Konradi and Tadafumi Kato

- Chapter 15: Integration and Consolidation: A Neurophysiological Model of Bipolar Disorder, Stephen M. Strakowski and Gin S. Malhi

- Index

Über Autor(innen)

Stephen M. Strakowski, MD, is Vice Dean for Research, and Associate Vice President, Regional Mental Health, Dell Medical School, University of Texas at Austin. He is an internationally recognized expert in the management of bipolar disorders, as a Best Doctor® and by US News and World Report® as a Top 1% Psychiatrist. His research focuses on the brain changes that occur at the onset of bipolar disorder.