Organofluorine Chemistry

Synthesis, Modeling, and Applications
1. Auflage 2021
ISBN: 978-3-527-34711-7
Verlag: WILEY-VCH

Buch, Englisch, 448 Seiten, Format (B × H): 175 mm x 252 mm, Gewicht: 1021 g

By presenting novel methods for the efficient preparation of fluorinated compounds and their application in pharmaceutical and agrochemical chemistry as well as medicine, this is a valuable source of information for all researchers in academia and industry!

Autoren/Hrsg.

Szabo, Kalman J.

Szabó, Kálmán J.

Selander, Nicklas

Fachgebiete

• Naturwissenschaften Chemie Physikalische Chemie Chemische Reaktionen, Katalyse
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren

Inhaltsverzeichnis

1. The Development of New Reagents and Reactions for Synthetic Organofluorine Chemistry by Understanding the Unique Fluorine Effects
2. Perfluoroalkylation Using Perfluorocarboxylic Acids and Anhydrides
3. Chemistry of OCF3, SCF3, and SeCF3 Functional Groups
4. Introduction of Trifluoromethylthio Group into Organic Molecules
5. Bifunctionalization-Based Catalytic Fluorination and Trifluoromethylation
6. Fluorination, Trifluoromethylation, and Trifluoromethylthiolation of Alkenes, Cyclopropanes, and Diazo Compounds
7. Photoredox Catalysis in Fluorination and Trifluoromethylation Reactions
8. Asymmetric Fluorination Reactions
9. The Self-Disproportionation of Enantiomers (SDE): Fluorine as an SDE-Phoric Substituent
10. DFT Modeling of Catalytic Fluorination Reactions: Mechanisms, Reactivities, and Selectivities
11. Current Trends in the Design of Fluorine-Containing Agrochemicals
12. Precision Radiochemistry for Fluorine-18 Labeling of PET Tracers

Über Autor(innen)

Kálmán J. Szabó is professor at the Department of Organic Chemistry at the Arrhenius Laboratory, Stockholm University (Sweden), since 2003. His major research interests are method development in organic synthesis, catalytic reactions, organoboron and organofluorine (including fluorine-18) chemistry. He is a member of the Royal Swedish Academy of Sciences and has authored over 150 publications. He is the editor of the book "Pincer and Pincer-Type Complexes" (Wiley-VCH).
 
Nicklas Selander is an assistant professor at the Department of Organic Chemistry at Stockholm University (Sweden), since 2018. His research interests include organic synthesis methodology, catalysis, and radical chemistry.