Tabrizi / Figueroa | Surrogate Approaches in Development of Antibody-Based Therapeutics: A Quantitative Evaluation | Buch | 978-1-4419-5776-4 | www.sack.de

Buch, Englisch, 400 Seiten, Format (B × H): 127 mm x 235 mm

Tabrizi / Figueroa

Surrogate Approaches in Development of Antibody-Based Therapeutics: A Quantitative Evaluation


2014
ISBN: 978-1-4419-5776-4
Verlag: Springer

Buch, Englisch, 400 Seiten, Format (B × H): 127 mm x 235 mm

ISBN: 978-1-4419-5776-4
Verlag: Springer


This book examines many important considerations necessary for the design of the most effective as well as science-based translational strategies necessary for the successful development of antibody-based therapeutics when surrogate approaches are employed.

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Research

Weitere Infos & Material


Mohammad Tabrizi, Ph.D.
Vice President, Preclinical Development, AnaptysBio, Inc.
Mohammad Tabrizi is a leader in translational sciences as related to development of antibody-based therapeutics. His product development experience spans many therapeutic areas including oncology and inflammatory disease, and his technical expertise includes preclinical pharmacology and safety, preclinical and clinical pharmacokinetics, pharmacodynamics, GLP-compliant bioanalytics, and clinical pharmacology of therapeutic monoclonal antibodies. He is currently the Vice President of Preclinical Development at AnaptysBio, Inc., a privately held biotechnology company in San Diego CA, USA, the leader in Somatic Hypermutation (SHM) for development of therapeutic antibodies where he advances the preclinical development efforts.
Gadi Gazit Bornstein, Ph.D.
Principal Scientist, AstraZeneca R&D Boston
Dr. Bornstein has experience in research and development with an emphasis in development of therapeutic monoclonal antibodies in oncology. Dr. Bornstein is a Principal Scientist at AstraZeneca, where he currently leads several antibody programs within the Preclinical oncology portfolio. He received his B.S. in biochemistry at the University of California, Davis and his doctoral degree in biochemistry at the Keck School of Medicine of the University of Southern California. Dr. Bornstein completed his postdoctoral training at Stanford University School of Medicine in the Division of Immunology and Rheumatology. Following his postdoctoral training, Dr. Bornstein joined Amgen Fremont, Inc. (formerly Abgenix, Inc.) as a Staff Scientist in the Preclinical Oncology department. During his tenure at Abgenix, he was a project team leader and lead biologist for multiple antibody programs.

Scott L. Klakamp, Ph.D.
Research Fellow, Biophysical Chemistry and Research Informatics, Takeda San Francisco
Scott Klakamp is one of the leading scientists in utilizing Biacore®, KinExA®, and FACS techniques to measure the binding kinetics and equilibrium constants of human monoclonal antibody/antigen complexes. He has extensive experience in research and development involving the biophysical and analytical characterization of biologics and monoclonal antibodies (mAb). He has also contributed significantly to the clinical immunology field by applying highly rigorous analytical detection concepts, previously unknown to the discipline, to immunogenicity studies of therapeutic mAbs. Currently, he is a Research Fellow at Takeda San Francisco, the therapeutic monoclonal antibody discovery engine for Takeda Pharmaceutical Company, and leads the Biophysical Chemistry and Research Informatics Groups.



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