The Hidden World of Protein Aggregation

Erscheinungsjahr 2024
ISBN: 978-0-443-29340-5
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 950 g

The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Specific chapters in this release include Protein Aggregation: An Overview, Pathways of Amyloid Fibril Formation and Aggregation, Factors Influencing Amyloid Fibril Formation, Morphological Features and Types of Aggregated Structures, Each big journey starts with a first step: Importance of Oligomerization, Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation, and more.

Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation.

Autoren/Hrsg.

Weitere Mitwirkende

Teplow, David B.

Dabirmanesh, Bahareh

Uversky, Vladimir N.

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

Preface
Bahareh Dabirmanesh and Vladimir N. Uversky
1. Protein Aggregation: An Overview
Vladimir N. Uversky
2. Pathways of Amyloid Fibril Formation and Aggregation
Bahareh Dabirmanesh and Fatemeh Aziziyan
3. Factors Influencing Amyloid Fibril Formation
Khosro Khajeh and Fatemeh Aziziyan
4. Morphological Features and Types of Aggregated Structures
Vladimir N. Uversky
5. Each big journey starts with a first step: Importance of Oligomerization
Vladimir N. Uversky
6. Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation
Vladimir N. Uversky
7. Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils
Bahareh Dabirmanesh and Farnoosh Farzam
8. Prediction of Protein Aggregation
Khosro Khajeh
9. Amyloid Fibril Cytotoxicity and Associated Disorders
Khosro Khajeh
10. Inhibitors of Amyloid Fibril Formation
Khosro Khajeh and Fatemeh Aziziyan
11. Therapeutic Approaches in Proteinopathies
Vladimir N. Uversky
12. Functional Amyloids
Bahareh Dabirmanesh
13. Biotechnological Applications of Amyloid Fibrils
Bahareh Dabirmanesh
14. The Hidden World of Protein Aggregation
Bahareh Dabirmanesh and Vladimir N. Uversky

Über Autor(innen)

Teplow, David B.
David B. Teplow, Ph.D., is a Professor of Neurology, Emeritus, at UCLA and an internationally recognized leader in efforts to understand and treat Alzheimer's disease. Dr. Teplow's group has used a multi-disciplinary approach to determine how neurotoxic peptides, such as the amyloid ß-protein (Alzheimer's disease) and a-synuclein (Parkinson’s disease), form neurotoxic structures that kill neurons and to develop the means to block these processes. Dr. Teplow received undergraduate training at UC Berkeley; a Ph.D. from the University of Washington; and was a postdoctoral scholar at Caltech. Before coming to UCLA, Dr. Teplow was a faculty member in the Department of Neurology, Harvard Medical School. Dr. Teplow has published >250 peer-reviewed articles, books and book chapters, and commentaries, in addition to serving on numerous national and international scientific advisory boards. Dr. Teplow was a founding editor of the Journal of Molecular Neuroscience and Current Chemical Biology, He is Editor-in-Chief of the Elsevier serial Progress in Molecular Biology and Translational Science and is Associate Editor-in-Chief of the American Journal of Neurodegenerative Disease.

Uversky, Vladimir N.
Vladimir N. Uversky is Professor in the Department of Molecular Medicine at the Morsani College of Medicine, University of South Florida. His research centers on protein folding, misfolding, and intrinsic disorder. He began his career at the Institute of Protein Research and the Institute for Biological Instrumentation in Russia, before moving to the University of California, Santa Cruz in 1998 and Indiana University–Purdue University Indianapolis in 2004, where he served as Senior Research Professor. He has been at USF since 2010 and is a Fellow of the Royal Society of Biology, the Royal Society of Chemistry, the American Institute for Medical and Biological Engineering, and the American Association for the Advancement of Science. Professor Uversky has authored numerous research papers and reviews and edited several books and book series on protein structure, folding, and misfolding. He serves as an editor for several scientific journals.

Dabirmanesh, Bahareh
Bahareh Dabirmanesh received her Ph.D. in Biochemistry from Tarbiat Modares University (Tehran-Iran) in 2013. Following the completion of her doctoral studies, she joined the University as an academic member pursuing both academic and research activities within the Department of Biochemistry, Faculty of Biological Sciences. During this period, she undertook the responsibilities of a supervisor or advisor for a considerable number of master's and PhD theses. Since 2022, she has held the position of associate professor. Her research interests are mainly focused on protein engineering, macromolecular interactions, structure-function relation, amyloidogenic proteins, Biotherapeutics, protein pathways and signaling cascades