The Matrix Metalloproteinases

Erscheinungsjahr 2026
ISBN: 978-0-443-47088-2
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 450 g

The Matrix Metalloproteinases, Volume 60 in The Enzymes series, explores recent advances in the study of matrix metalloproteinases (MMPs), a critical family of enzymes involved in extracellular matrix remodeling and numerous physiological and pathological processes. This volume presents a comprehensive collection of chapters covering key aspects of MMP biology, including their structure, function, regulation, and detection through activity-based probes.

Chapters in this release examine classical and selective MMP inhibitors, including specific targeting strategies for MMP-13, as well as the role of endogenous tissue inhibitors of metalloproteinases. Additional contributions explore the involvement of MMPs in various biological and disease contexts, including oral diseases, neurodegenerative disorders, neutrophil biology, and cancer progression.

The volume also addresses current challenges and opportunities in the design of MMP-targeted therapeutics, highlighting advances in drug development and pharmacological applications. Together, these chapters provide valuable insights into the biochemical, physiological, and clinical significance of MMPs, making this volume an essential reference for researchers in enzymology, biochemistry, molecular biology, and biomedical sciences.

Autoren/Hrsg.

Weitere Mitwirkende

Supuran, Claudiu T.

Dufour, Antoine

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

1. Overview on Matrix Metalloproteinases (MMPs)
2. Activity-Based Probes to Detect MMP Activity
3. Classical MMP Inhibitors
4. Design of Selective MMP Inhibitors
5. MMP-13 Selective Inhibitors
6. Tissue Inhibitors of MMPs
7. MMPs in Oral Diseases
8. MMPs in Neurodegenerative Diseases
9. Role of MMPs in Neutrophil Biology
10. Role of MT1-MMP in Ovarian Cancer
11. Challenges and Opportunities in the Drug Design and Pharmacological Applications of MMP Inhibitors

Über Autor(innen)

Supuran, Claudiu T.
Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields.

Dufour, Antoine
Dr. Antoine Dufour has joined the Department of Physiology and Pharmacology as an Assistant Professor. Dr. Dufour obtained his BA (Hons.) in Chemistry from the State University of New York at Oswego, his MSc and PhD in Chemical Biology from the Stony Brook University (2010). He completed a Postdoctoral Fellowship in Biochemistry at the University of British Columbia in 2017 under the supervision of Dr. Chris Overall. Antoine’s research is focused on the role of proteases in immunity and novel drug target identification in inflammatory musculoskeletal diseases, with a particular interest in quantitative mass spectrometry and systems biology. He owns two patents for the inhibitory methods of protease-mediated cell migration. His research program aims to understand the key mechanisms of inflammatory and immune responses in musculoskeletal diseases. Antoine has already published 20 journal papers, 3 book chapters and has an outstanding track record of academic awards. Dr. Dufour’s lab and office space is located at the Centre for Mobility and Joint Health on the third floor of the HRIC building.