Primary Adrenal Malignancies

2025
ISBN: 978-3-031-62300-4
Verlag: Springer Nature Switzerland

Buch, Englisch, 176 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 295 g

Reihe: Updates in Surgery

Dissemination of knowledge is the best and only strategy capable of improving clinical management in rare and ultra-rare malignancies, including primary adrenal malignancies. It is preliminary to any further healthcare policy such as, for example, the centralization of cases in referral institutions.

Adrenal primary malignancies are probably the rarest among rare pathologies. This epidemiological consideration is at the origin of a vicious circle: the lack of preoperative diagnosis leads to inappropriate surgical procedures and to inadequate follow-up and systemic therapy strategies. Furthermore, when malignancy is recognized, the relative role of systemic, surgical, or other local ablative techniques is often misinterpreted. All this produces a negative impact on survival, also in patients who could have been cured with a correct therapeutic strategy.

This open access book provides a user-friendly exploration of these rare conditions, using a transversal approach common in modern precision medicine. The text covers various clinical aspects, including epidemiology, genetics, molecular medicine, imaging, and surgery. Guidelines for managing syndromic situations are provided. The book thoroughly addresses all the different surgical issues and emphasizes the importance of pathology in assessing prognosis. The pivotal role of medical oncologists in managing these patients is explored, along with alternative treatments such as nuclear medicine and radiotherapy. Finally, the book highlights the latest preclinical research and its implications for translational medicine.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Tiberio, Guido A. M.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren

Inhaltsverzeichnis

1. Epidemiology, Presentation, Staging, and Prognostic Factors in Adrenocortical Carcinoma.- 2. Epidemiology, Presentation, Staging, and Prognostic Factors in Malignant Pheochromocytoma.- 3. Genetics and Molecular Biology of Adrenocortical Carcinoma.- 4. Genetics and Molecular Biology of Pheochromocytoma and Paraganglioma.- 5. Imaging in Adrenocortical Carcinoma and Malignant Pheochromocytoma.- 6. Management of Endocrine Syndromes Associated with Adrenocortical Carcinoma.- 7. Management of Hereditary Syndromes Associated with Pheochromocytoma/Paraganglioma.- 8. Adrenal Incidentaloma.- 9. Surgery for Adrenocortical Carcinoma.- 10. Adrenocortical Carcinoma with Vena Cava Involvement.- 11. Adrenocortical Carcinoma: the Posterior Minimally Invasive Approach.- 12. Surgery for Malignant Pheochromocytoma.- 13. Open or Laparoscopic Surgery in the Management of Adrenocortical Carcinoma?.- 14. Pathology of Adrenocortical Carcinoma and Malignant Pheochromocytoma.- 15. Medical Treatment in Advanced Adrenocortical Carcinoma.- 16. Integrated Approach in Locally Advanced, Oligometastatic or Recurrent Adrenocortical Carcinoma.- 17. Medical Treatment of Malignant Pheochromocytoma.- 18. Role of Radiotherapy in Adrenocortical Carcinoma and Pheochromocytoma.- 19. Radionuclide Treatment in Malignant Pheochromocytoma.- 20. Preclinic and Translational Research in Adrenal Malignancies.

Über Autor(innen)

Professor Tiberio started his academic career as an Assistant Professor of General Surgery at the University of Brescia in 1995. From 1997 to 1998 he worked as Assistant étranger en Chirurgie Générale et Digestive at the Université Luis Pasteur in Strasbourg, France. In 2000 he was appointed Associate Professor of General Surgery at the University of Brescia. Full Professor of General Surgery from 2006, he served at the Campus Bio-Medico University in Rome and, from 2012, at the University of Brescia. His surgical activity is mainly carried out as a Senior Consultant at ASST Spedali Civili di Brescia, a regional tertiary university hospital. His areas of main interest include digestive (with particular emphasis on gastric neoplasms), hepatic, pancreatic and adrenal surgery, emergency surgery and surgery of peritoneal surface malignancies. Prof. Tiberio’s scientific activity addresses both clinical research and basic science with translational interest.