Integrative Omics in Parkinson's Disease

Erscheinungsjahr 2024
ISBN: 978-0-443-13550-7
Verlag: Elsevier Science

Buch, Englisch, 274 Seiten, Format (B × H): 150 mm x 229 mm, Gewicht: 399 g

Integrative Omics in Parkinson’s Disease provides a comprehensive understanding of the current literature on high-throughput technologies relating to discoveries for Parkinson's disease etiology. This emerging field uses large omics datasets to investigate the etiology of Parkinson’s disease and other forms of parkinsonism. The book traces the evolution of omics technologies from the discovery of monogenic Parkinson's disease forms. Chapters delve into genomics, transcriptomics, epigenomics, artificial intelligence, and gene-environment interactions. Furthermore, it examines the potential therapeutic applications of these advancements and provides insights into the future of omics research in Parkinson's disease.

Autoren/Hrsg.

Trinh, Joanne

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft

Inhaltsverzeichnis

1. Introduction: evolution of omics
2. Monogenic and Complex genetics PD
3. Genetic risk scores
4. Mendelian Randomization
5. Methods to investigate somatic structural variants in synucleinopathies
6. Mitochondrial genetics
7. Epigenetics in PD genes
8. The microbiome
9. Genetic modifiers in reduced penetrance: X-linked dystonia
10. Long-read transcriptomics in neurodegeneration
11. Gene-environment interactions and behaviour
12. Introduction to prediction modeling using machine learning and omics data
13. IPSCs and OMICs merging