Heterocyclic Compounds as Pharmaceutical Ingredients

1. Auflage 2026
ISBN: 978-1-394-28480-1
Verlag: Wiley

Buch, Englisch, 576 Seiten

Unlock the therapeutic potential of N-, O-, and S-based heterocycles with this comprehensive guide to the synthesis, characterization, and biological interactions of the compounds currently redefining modern drug design.

Heterocyclic compounds have proven their potential as active pharmaceutical ingredients due to the presence of N, O, and S in their chemical makeup, making them ideal hydrogen bond acceptors. Recently, a large number of heterocyclic compounds have been documented as drugs after clearing all phases of preclinical and clinical trials and are commercially available worldwide. This book provides a comprehensive look at the active profile of heterocyclic compounds and their potential applications as antibacterial, antiviral, anti-inflammatory, and anti-cancer agents, as well as applications in pharmaceutical chemistry, pharmacy, cheminformatics, bioinformatics, and related fields. It covers synthesis and characterization, biological interaction mechanisms, proteomics and genotypic activity, and their role in treating diseases including cancer and AIDS. It also addresses challenges such as bioavailability and toxicity, making it a valuable resource for researchers, students, and professionals in drug design using heterocycles.

Autoren/Hrsg.

Tripathy, Divya Bajpai

Chhabra, Priyanka

Gupta, Anjali

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Chemische Verfahrenstechnik

Inhaltsverzeichnis

Preface xvii

1 Heterocyclic Molecules as an Active Pharmaceutical Ingredient: An Introduction 1
Anushka Sharma, Awaneet Kaur, Pranav Gupta, Debashis Paramanick and Abdulsalam Alhalmi

2 Biologically Active Nitrogen Heterocyclic Compounds 27
Diwakar Chauhan, Monika Chauhan, Priya Tyagi and Amrita Kaushik

3 Heterocyclic Compounds as Antimicrobial (Antibacterial, Antifungal, Antiviral, and Anthelmintics) Agent 61
Gaurank Pal, Devaang Mathur, Lakshit Srivastav, Vishal Mehare, Ajay Gupta, Shruti Khanna Ahuja and Puja Prasad

4 Heterocyclic Compounds as Anticancer Agents 123
Aadya Singh, Priyanshi Kamboj, Pragya Swami, Puja Prasad and Shruti Khanna Ahuja

5 Heterocyclic Compounds as Anti-Inflammatory Agents 179
Hemlata Nimesh, Sagar Kumar and Nidhi Srivastava

6 Heterocyclic Compounds as Antioxidant Agents 207
Niranjan Kaushik, Shristi Singh, Ajita Paliwal and Sachin Chaudhary

7 Heterocyclic Compounds as Anticonvulsants, Antipyretics, Antiallergic Agents, and Antileprosy Agents 249
Anushka Sharma, Awaneet Kaur, Pranav Gupta, Debashis Paramanick and Abdulsalam Alhalmi

8 Heterocyclic Compounds as Antihistamine Agents 269
Avinash Jha, Saurabh Sharma, Deepika Paliwal, Aman Thakur and Saurabh Srivasatva

9 Heterocyclic Compound Having Herbicides Activity 307
Niranjan Kaushik, Mridul Singh Sengar, Deepika Paliwal and Nadeem Ahmad Siddique

10 Heterocyclic Compounds as Antihypertensive Agents 349
Manjot Singh, Deepika Paliwal, Aman Thakur, Manvi Karayat and Saurabh Srivasatva

11 In Silico Studies on Heterocyclics as an Active Pharmaceutical Agent 389
Anurag Paul, Debanjali Adhikary, Abdul Kareem Parchur, Gayatri Sharma and Apoorva Mishra

12 Piperazine Derivatives: Potential Antimicrobial Agents 407
R. Prathap, Rashmi Dubey, Anjali Gupta and Divya Bajpai Tripathy

13 Synthetic Drug Discovery Strategy of Benzimidazole Derivatives and Their Applications 443
Prasad Vijay Korake, Diwakar Chauhan and Subhalaxmi Pradhan

14 Synthesis and Biological Evaluation of Thiophene- and Piperazine-Based Active Compounds 475
Ayyagari Subramanya Sharma, Subhalaxmi Pradhan and Prashant Kumar

15 Heterocyclic Compounds as Antileprotic Agents 509
Sanjita Das, Anjali Singh, Shalini Gautam and Gyas Khan

16 Bromodomains: Biomedical Applications of Active Ingredients 531
Sweta Raj, Anjan Kumar Nayak, Harsh Vardhan and Divya Bajpai Tripathy

References 543
Index 547

Über Autor(innen)

Divya Bajpai Tripathy, PhD is a Professor in the Department of Chemistry in?the School of Basic and Applied Sciences at Galgotias University with more than 15 years of experience in teaching, research, and academic leadership. She has published more than 130 peer-reviewed research papers, authored and edited 11 books, and contributed more than 35 book chapters. Her research focuses on interdisciplinary applications of chemistry in healthcare, environmental remediation, advanced materials, and biomedical technologies.

Priyanka Chhabra, PhD is an Assistant Professor in the Amity Institute of Biotechnology at Amity University, with a background spanning teaching, research, and industry in biotechnology and allied fields.

Anjali Gupta, PhD is a Professor in the Department of Chemistry at Galgotias University. She has authored influential research and review articles and served as a principal investigator on multiple projects. Her research focuses on biomaterials, MOF-based materials, anti-corrosive coatings, water remediation, and bioactive compounds.