Buch, Englisch, Band 1158, 277 Seiten, Paperback, Format (B × H): 178 mm x 254 mm, Gewicht: 612 g
Buch, Englisch, Band 1158, 277 Seiten, Paperback, Format (B × H): 178 mm x 254 mm, Gewicht: 612 g
Reihe: Advances in Experimental Medicine and Biology
ISBN: 978-981-1383-69-4
Verlag: Springer Nature Singapore
Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Chapter 1. Mitochondrial Metabolism in Cancer. A Tangled Topic. Which Role for Proteomics? (Roberto Scatena).- Chapter 2. Mitochondrial Proteins in the Development of Parkinson's Disease (Mauro Fasano and Tiziana Alberio).- Chapter 3. Role of Mitochondria in Host-Pathogen Interaction (Alessio Soggiu).- Chapter 4. Mitochondria Lysine Acetylation and Phenotypic Control (Federica Ciregia).- Chapter 5. Crosstalk Between Oxidative Stress and Mitochondrial Damage: Focus on Amyotrophic Lateral Sclerosis (Viviana Greco).- Chapter 6. A Tag-Based Affinity Purification Mass Spectrometry Workflow for Systematic Isolation of the Human Mitochondrial Protein Complexes (Zhuoran Wu).- Chapter 7. Targeted Proteomics to Study Mitochondrial Biology (Rainer Bischoff and Karin Wolters).- Chapter 8. Recent Advances in Targeting Human Mitochondrial AAA+ Proteases to Develop Novel Cancer Therapeutics (Walid Houry).- Chapter 9. Investigating the Role of Mitochondria in Type 2 Diabetes – Lessons from Lipidomics and Proteomics Studies of Skeletal Muscle and Liver (Albert Sickmann).- Chapter 10. Quantification of Mitochondrial Network Characteristics in Health and Disease (Jeff Stuart).- Chapter 11. Cysteine Switches and the Regulation of Mitochondrial Bioenergetics and ROS Production (Ryan Mailloux).- Chapter 12. Advances Towards Therapeutic Approaches for mtDNA Disease (Timothy Shutt).- Chapter 13. Mitochondrial Genetics (Vanessa Goncalves).- Chapter 14. Heteroplasmy Shifting as Therapy for Mitochondrial Disorders (Neal Sondheimer).- Chapter 15. Mitochondrial Function and Dysfunction in Alzheimer’s Disease (Benedict Albensi).- Chapter 16. Application of CRISPR-Cas9 Screening Technologies to Study Mitochondrial Biology in Healthy and Disease States (Steven Chan).