Polarization-Based Optical Imaging for Clinical Diagnostics

1. Auflage 2026
ISBN: 978-3-527-41469-7
Verlag: Wiley-VCH GmbH

Buch, Englisch, 496 Seiten, Format (B × H): 218 mm x 280 mm, Gewicht: 1590 g

Unified polarization imaging theory for preclinical disease detection and diagnostics

Detecting pathological tissue changes before clinical symptoms emerge requires imaging methods with high structural sensitivity. Polarization-Based Optical Imaging for Clinical Diagnostics presents a unified phenomenological theory integrating polarization interferometry, Mueller and Jones matrix mapping, digital holography, and phase scanning. Edited by a team of optical physicists with collectively over 1,000 Scopus-indexed publications, this reference establishes a coherent framework for 3D Jones-Mueller digital holographic mapping of biological tissues and fluids.

The book details physical principles, experimental optical systems, and data analysis algorithms combining statistical, fractal, and wavelet approaches to differentiate pathological states with precision. Clinical applications span oncology, cardiology, gynecology, and forensic medicine, each demonstrated through concrete diagnostic scenarios. Software tools and image libraries accompany the methodology, enabling direct implementation of polarization-based diagnostic protocols in laboratory and clinical settings.

Readers will also find: - A unified phenomenological framework connecting polarization interferometry, Mueller matrix mapping, Jones matrix mapping, digital holography, and phase scanning techniques
- Detailed algorithms for statistical, fractal, and wavelet analysis applied to optical mapping data from biological tissues and fluids
- Clinical diagnostic applications in oncology, cardiology, gynecology, and forensic medicine with pathological state differentiation methods
- Software tools and image libraries supporting direct implementation of 3D Jones-Mueller digital holographic mapping protocols
- Experimental system designs for polarization-based optical mapping enabling non-invasive preclinical detection of cancer, diabetes, and cardiovascular conditions

Polarization-Based Optical Imaging for Clinical Diagnostics serves biophysicists, clinical physicists, radiologists, and biomedical engineers seeking a rigorous, application-ready reference for polarization-based tissue characterization. By unifying theory, experimental methodology, and clinical validation in a single volume, it equips researchers and practitioners to advance non-invasive preclinical diagnostics.

Autoren/Hrsg.

Ushenko, Yurii

Dou, Weidong

Ushenko, Oleksandr

Dubolazov, Oleksandr

Soltys, Iryna

Fachgebiete

• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren

Inhaltsverzeichnis

PART I: METHODS AND SYSTEMS OF OPTICAL MAPPING IN BIOMEDICAL RESEARCH
1. Overview of modern optical mapping techniques
1.1 Diffuse, fluorescence molecular, bioluminescence, photoacoustic, laser coherent, andlaser polarization-sensitive systems
1.2 Unsolved problems and proposed solutions via 3D Jones-Mueller digital holographic mapping

PART II: PHYSICAL PRINCIPLES, ALGORITHMS AND METHODS OF 3D JONES-MUELLER DIGITAL HOLOGRAPHIC MAPPING
 
2. Physical principles of 3D Jones-Mueller digital holographic mapping
2.1 Phenomenological models of optically anisotropic tissue and fluid samples
2.2 Reconstruction of optical anisotropy parameters (linear and circular birefringence and
dichroism)
3. Algorithms and methods of 3D Jones-Mueller digital holographic mapping
3.1 Digital holographic reconstruction and phase scanning
3.2 Multichannel polarization-interference measurement and reconstruction of anisotropy
maps
4. Basic algorithms for processing 3D Jones-Mueller digital holographic mapping data
4.1 Statistical analysis
4.2 Correlation analysis
4.3 Wavelet analysis
4.4 Multifractal analysis
4.5 Singular analysis
 
PART III: BIOMEDICAL AND CLINICAL APPLICATIONS OF 3D JONES-MUELLER DIGITAL HOLOGRAPHIC MAPPING
 
5. Diagnostic efficiency of 3D Jones-Mueller digital holographic mapping
5.1 Phase waves of local depolarization in biological tissues
5.2 Differential Mueller-matrix mapping of polycrystalline tissue components
5.3 Optical interference approach for tumor differentiation
5.4 Wavelet-enhanced polarimetry for cancer analysis
5.5 Holographic scanning of myocardial layers
5.6 Holographic histology for necrotic tissue differentiation (forensics)
5.7 Imaging of blood film microstructure
6. Diagnostic efficiency of 3D Jones-digital holographic mapping
6.1 Mapping of biological fluid facies
6.2. Jones matrix tomography
6.2 Multifractal scanning for COVID-19 diagnostics
6.3 Scanning of blood plasma films for organ pathology
6.4 Polarimetry of blood films for thyroid pathology
 
Appendices
A1. Programs for 3D Jones-Mueller holographic reconstruction
A2. Programs for layer-by-layer reconstruction of polycrystalline structures
A3. Programs for statistical and correlation data analysis
A4. Album of Mueller matrix images
A5. Album of optical anisotropy maps
 
Conclusion

Über Autor(innen)

Yurii Ushenko, PhD, is a physicist and computer scientist affiliated with Shaoxing University in China and Yuriy Fedkovych Chernivtsi National University in Ukraine. His research focuses on biophotonics, optical imaging, and digital holography for biomedical diagnostics.
 
Weidong Dou, PhD, is a physicist at Shaoxing University, China. His expertise lies in laser optics and biomedical imaging systems, with a focus on developing advanced diagnostic technologies using polarization-sensitive methods.
 
Oleksandr Ushenko, PhD, is a researcher in multimedia and optical technologies at Yuriy Fedkovych Chernivtsi National University. His work centers on digital holography and optical mapping techniques for clinical applications.
 
Oleksandr Dubolazov, PhD, is a specialist in printing and optical technologies at Yuriy Fedkovych Chernivtsi National University. He contributes to algorithm development for biomedical image analysis and optical diagnostics.
 
Iryna Soltys, PhD, is a researcher in optical technologies at Yuriy Fedkovych Chernivtsi National University. Her interests include polarization imaging and the application of digital holography in medical diagnostics.