Methods in Bioengineering: Organ Preservation and Reengineering

Erscheinungsjahr 2011
ISBN: 978-1-60807-013-8
Verlag: Artech House

Buch, Englisch, 282 Seiten

Written and edited by recognized experts in the field, the new Artech House Methods in Bioengineering book series offers detailed guidance on authoritative methods for addressing specific bioengineering challenges. Offering a highly practical presentation of each topic, each book provides research engineers, scientists, and students with step-by-step procedures, clear examples, and effective ways to overcome problems that may be encountered. This first-of-its-kind volume addresses the important challenge of organ preservation and reengineering. The book presents cutting-edge techniques for damaged livers and hearts via normothermic perfusion, hypothermic machine perfusion for the liver, kidney and pancreas, and imaging techniques to assess the viability of injured kidneys. Professionals and researchers also find methods to decellularize whole organs to create scaffolds for tissue engineering. Moreover, the book presents an approach to enhancing hepatocyte recovery from marginal livers.

Autoren/Hrsg.

Uygun, Korkut

Lee, Charles Y.

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Medizinische Biotechnologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Naturwissenschaften Physik Angewandte Physik Medizinische Physik
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Naturwissenschaften, Technik, Medizin

Inhaltsverzeichnis

Introduction. Part 1: Preservation – Normothermic Machine Perfusion of the Liver. Heart Preservation: Conventional vs. Novel Techniques. Hypothermic Machine Perfusion of the Kidneys. Hypothermic Machine Perfusion of the Livers. Hypothermic Perfusion of the Pancreas: Emphasis on Preservation prior to Islet Isolation. Methods of Cardiac Oxygen Persufflation. Vascular Oxygen Persufflation for Preservation and Reconditioning of Marginal Liver Grafts. Use of Optical Imaging and Spectroscopy in Assessment of Organ Perfusion. Part 2: Reengineering – Preparation of a Transplantable Liver Graft by Recellularization of Decellularized Whole Organs. Engineering Lung Tissue. Detergent-Enzymatic Method for Bioengineering Human Airways. Ex Vivo Perfusion of Rat Liver Grafts for Hepatocyte Retrieval. Technique of Clinical Vascular Isolation and Perfusion of the Liver.

Über Autor(innen)

Uygun, Korkut
Korkut Uygun is the leader of the Organ Engineering Group at Massachusetts General Hospital, where he was instrumental in developing a technique that promises to allow growth of transplantable replacement livers. Dr. Uygun received his Ph.D. in chemical engineering from Wayne State University.

Lee, Charles Y.
Charles Y. Lee is an associate professor in the Department of Medical Engineering at the University of North Carolina, Charlotte. Dr. Lee earned his Ph.D. in mechanical engineering from the University of California, Berkeley.

Korkut Uygun is the leader of the Organ Engineering Group at Massachusetts General Hospital, where he was instrumental in developing a technique that promises to allow growth of transplantable replacement livers. Dr. Uygun received his Ph.D. in chemical engineering from Wayne State University.

Charles Y. Lee is an associate professor in the Department of Medical Engineering at the University of North Carolina, Charlotte. Dr. Lee earned his Ph.D. in mechanical engineering from the University of California, Berkeley.