Buch, Englisch, 386 Seiten, Print PDF, Format (B × H): 189 mm x 246 mm, Gewicht: 745 g
The Dual Role of DNA in Life and Death
Buch, Englisch, 386 Seiten, Print PDF, Format (B × H): 189 mm x 246 mm, Gewicht: 745 g
ISBN: 978-0-19-856923-7
Verlag: OUP Oxford
Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Geriatrie, Gerontologie
- Naturwissenschaften Biowissenschaften Molekularbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
- Naturwissenschaften Biowissenschaften Biowissenschaften Evolutionsbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Wachstum, Entwicklung, Altern
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
- Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen
- Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Industrielle Biotechnologie
Weitere Infos & Material
- Preface
- 1: Introduction
- 2: The Logic of Aging
- 3: Genome Structure and Function
- 4: Genome Maintenance
- 5: Genome Instability and Accelerated Aging
- 6: The Aging Genome
- 7: From Genome to Phenome
- 8: A Genomic Limit to Life?
- References and Glossary
- Literature References
