Toxoplasma Gondii

The Model Apicomplexan - Perspectives and Methods
4th Auflage
ISBN: 978-0-443-45048-8
Verlag: Elsevier Science

Buch, Englisch, 1000 Seiten, Format (B × H): 191 mm x 235 mm

Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods, Fourth Edition offers a comprehensive approach and balance between historical research, new developments, and innovative approaches to Toxoplasma gondii research. Completely updated and revised, the Fourth Edition aims to provide a better understanding of the structure, genetic diversity, and population biology of T. gondii. It details the immunology, molecular, and cellular biology of Toxoplasma gondii combined with new molecular techniques, methods, and resources for working with this pathogen. The new edition also offers the latest information concerning epidemiology, diagnosis, treatment, and prevention of toxoplasmosis. With contributions from leading experts in the field, Toxoplasma Gondii, Fourth Edition is an essential one-stop resource for a wide range of researchers, scientists, and clinicians engaged in the study of T. gondii and toxoplasmosis.

Autoren/Hrsg.

Weiss, Louis M.

Kim, Kami

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
• Medizin | Veterinärmedizin Veterinärmedizin Veterinärmedizin: Bakteriologie, Virologie, Parasitologie
• Naturwissenschaften Biowissenschaften Parasitologie
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

1. The history and life cycle of Toxoplasma gondii
2. The ultrastructure of Toxoplasma gondii
3. Cryo-EM to define the Toxoplasma gondii conoid and other structures
4. Molecular epidemiology, population structure of Toxoplasma gondii
5. Human Toxoplasma infection
6. Ocular disease due to Toxoplasma gondii
7. One Health: Toxoplasmosis in wild and Domestic Animals
8. Toxoplasma animal models and therapeutics
9. Toxoplasma gondii: lipid synthesis and uptake and host cell interactions
10. Metabolic networks and metabolomics
11. The apicoplast, mitochondrion and mitoribosomes of Toxoplasma gondii
12. Calcium and cyclic nucleotide signalling networks in Toxoplasma gondii
13. Toxoplasma secretory proteins and their roles in parasite cell cycle and infection
14. Endomembrane trafficking pathways in Toxoplasma
15. The Toxoplasma cytoskeleton: structures, proteins, and processes
16. Toxoplasma gondii: secreted effectors and host cell manipulation
17. Bradyzoite and sexual stage development in Toxoplasma gondii
18. Development and application of classical genetics in Toxoplasma gondii
19. Genetic manipulation of Toxoplasma gondii
20. Regulation of gene expression in Toxoplasma gondii
21. Identification of subcellular proteome using hyperLOPIT
22. Cerebral toxoplasmosis
23. Innate immunity to Toxoplasma gondii
24. Adaptive immunity to Toxoplasma gondii
Appendix A: The effect of murine gene deficiencies on the outcome of Toxoplasma gondii infection
Appendix B: Databases and Scientific Resources for Toxoplasma gondii Research

Über Autor(innen)

Weiss, Louis M.
Louis M. Weiss, MD, MPH is Professor of Medicine (Division of Infectious Diseases) and Professor of Pathology (Division of Parasitology and Tropical Medicine) of the Albert Einstein College of Medicine, Bronx, New York. Dr. Weiss received his M.D. and M.P.H degrees from the Johns Hopkins University in 1982. He then completed a residency in Internal Medicine at the University of Chicago and a fellowship in Infectious Diseases at the Albert Einstein College of Medicine. Following this fellowship, he joined the faculty at Einstein where he is currently a Professor of Pathology and Medicine. His laboratory group has an active research program on parasitic diseases with a research focus on Toxoplasma gondii, the Microsporidia and Trypanosoma cruzi. Dr. Weiss is the author of over 200 publications and the editor of 3 books on parasitology. He is a fellow of the American College of Physicians, Infectious Disease Society of America and the American Academy of Microbiology. Dr. Weiss is the Co-Director of the Einstein Global Health Center.

Kim, Kami
Dr. Kami Kim is a physician-scientist who joined the USF faculty in 2017 as a Professor of Internal Medicine (Infectious Diseases and International Medicine) and Professor of Global Health. Her laboratory focuses upon understanding the pathogenesis of toxoplasmosis and malaria, parasitic diseases of global significance. The Toxoplasma projects use a multidisciplinary systems biology approach to understand how the parasite senses and responds to changes in its host. Using a combination of epigenomics, genetics and proteomics, her group is studying how the parasite transitions from the pathogenic tachyzoite form to the persistent bradyzoite form. She is investigating the epigenetic and genetic factors that govern the host response to parasites. Dr. Kim is a fellow of the American Academy of Microbiology and the Infectious Disease Society of America as well as an elected member of the Association for American Physicians and the American Society for Clinical Investigation.